Experimental bronchopneumopathy due to SO2 in the dog

Lulling, J.; Prignot, J; Lievens, Patricia

doi:10.1007/bf00537865

Cited by 15 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Boissier et al (1971) obtained dose-related decreases in pulmonary airways resistance in response to isoprenaline, but in our preliminary experiments the responses obtained were small and dose-response relations were inadequate. This may have been because resting pulmonary resistance was low, as has also been observed in anaesthetized animals by other workers (Lulling, Prignot & Lievens, 1968). Since satisfactory dose-response curves to isoprenaline are obtained by measuring the inhibitory effect of the drug against acetylcholine-induced increases in pulmonary resistance (Daly, Farmer & Levy, 1971), this method was adopted for use in the present experiments.…”

Section: Preparation Of Animalsmentioning

confidence: 79%

The SELECTIVITY OF Β‐ADRENOCEPTOR ANTAGONISTS ON CARDIOVASCULAR AND BRONCHODILATOR RESPONSES TO ISOPRENALINE IN THE ANAESTHETIZED DOG

Daly¹,

Flook²,

Levy³

1975

British J Pharmacology

View full text Add to dashboard Cite

1The actions of five 1-adrenoceptor antagonists, chosen because of reported differences in their selectivities, were compared using the positive chronotropic, vasodepressor and bronchodilator responses to isoprenaline in anaesthetized dogs. 2 Propranolol was a potent antagonist of the isoprenaline responses in all three systems. 3 Practolol and acebutolol (M & B 17,803) blocked the positive chronotropic responses to isoprenaline to a greater extent than the vasodepressor or bronchodilator responses. 4 Butoxamine and a-methyl dichloroisoprenaline showed the opposite selectivity, blocking the vasodepressor and bronchodilator responses to isoprenaline to a greater extent than positive chronotropic responses. However, both drugs were considerably less potent than the other antagonists studied and their selectivities were less clear-cut than those of practolol or acebutolol. 5 All the antagonists lowered the resting heart rate and to a lesser extent the diastolic blood pressure. The effects of propranolol, practolol and acebutolol on heart rate probably result from cardiac f-adrenoceptor blockade. With butoxamine and a-methyl dichloroisoprenaline, however, the effects on heart rate probably result from a direct cardiodepressant action. 6 The relevance of the results to the problem of the sub-classification of ,B-adrenoceptors is discussed.

show abstract

Section: Preparation Of Animalsmentioning

confidence: 79%

The SELECTIVITY OF Β‐ADRENOCEPTOR ANTAGONISTS ON CARDIOVASCULAR AND BRONCHODILATOR RESPONSES TO ISOPRENALINE IN THE ANAESTHETIZED DOG

Daly¹,

Flook²,

Levy³

1975

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…Furthermore, we found a slight increase of the serous parts of the bronchial glands which varied in different lung areas of the dogs. Corresponding to other authors we regard this as an effect of the SO2 exposition (Lamb, 1968;Lulling et al, 1968;Mawdesley-Thomas et al, 1970;Reid, 1970).…”

Section: Discussionmentioning

confidence: 81%

“…On the basis of this report (Lulling et al, 1968) dog has been prefered in this study to produce a model of chronic obstructive bronchitis by exposing to high concentration of SO2. Airway resistance (Rt) and intrathoracic gas volume (IGV) have been measured at regular interval during the experimental period.…”

mentioning

confidence: 97%

See 1 more Smart Citation

Respiratory damage caused by long-term inhalation of high concentration of sulphur-dioxide in dogs

1977

View full text Add to dashboard Cite

It has been tried in this study to produce chronic obstructive bronchitis in dogs by exposing them to high concentrations of SO2. The study was extended to 175 days and during that period the animals were exposed to 300-500 ppm SO2 for a total of 435 h. None of the three dogs developed serious respiratory damage. Most of the symptoms were transitory. Histological examinations showed increased number of goblet cells in trachea, main- and lobar bronchi and a slight alteration of the bronchial glands.

show abstract

“…In long-term canine studies (table 6), its concentration has been varied by more than three orders of magnitude (0.3-720 mg·m -3 ). At high levels of exposure, an increased prevalence both of chronic bronchitis [26, 34-36, 41, 42] and emphysematous lesions has been observed [26]. At lower levels of exposure, respiratory responses were similar to those observed at high levels, but they occurred later.…”

Section: Sulphur(iv)mentioning

confidence: 83%