Passive energy dissipation systems and devices are helpful in mitigating the danger of earthquake damage to structures. Metallic slit dampers (MSDs) are one of the most efficient and cost-effective solutions for decreasing seismic energy intake. The potential importance of MSDs in managing vibrations and limiting structural fatigue continues to grow as research advances and new materials and designs are introduced. This study evaluated the seismic performance of single-plate MSDs (SPMSDs) through a combination of numerical simulation and assessment of experimental results. ABAQUS software was used to create an assembly consisting of endplates, bolts, and SPMSDs. A real-world earthquake scenario was simulated using cyclic loads based on ASCE/SEI standards, and displacement-measuring devices such as strain gauges and LVDT were employed to record the behavior of the SPMSDs. The results of the experiment are used to assess the compliance of the SPMSDs and discuss their behavior as they undergo minimum and maximum displacements due to minimum and maximum applied forces. The energy dissipation capabilities of the dampers are presented by analyzing and comparing the area of their hysteresis loops, equivalent viscous damping, and their damping ratios. Actual failure modes are identified and shown to describe the limitations and potential vulnerability of the dampers. The relative error between the lowest and greatest recorded forces from experimental data and numerical simulation ranges from 4.4% to 5.7% for SPMSD 1 and from 1.6% to 2.1% for SPMSD 2, respectively. These deviation values represent a satisfactory level of precision, demonstrating that the numerical simulation accurately predicts the actual performance and behavior of the dampers when subjected to cyclic stress. The topology optimization performed in this study yielded an improved geometry of the SPMSD suited for a corresponding maximum considered earthquake (MCER) displacement of ±33 mm. This research also suggests practical implementations of the investigated and improved SPMSDs.