The waste generated from the process of steel shot blasting must be safely disposed of due to its classification, non-hazardous and non-inert, and, consequently, is sent to landfills. One of the possibilities for reusing this waste is in the cement materials industry. In this context, the aim of this study was to evaluate the addition of waste from steel shot blasting, thereby replacing natural sand, for the manufacture of cementitious material with properties that shield against ionizing radiation. Three forms of steel shot (commercial steel shot—AG1, intermediate steel shot waste—AG2, and steel shot dust—AG3) were used to replace natural sand in different proportions (0%, 10%, 20%, 30%, and 40% by volume). Compressive strength results were found with values above the minimum compressive strength (20 MPa) requirement of structural concrete. The results indicated that AG1, AG2, and AG3 can be used to attenuate X-ray radiation. Regarding the reference samples (mortar developed without natural sand replacement), an increase in X-ray shielding of 76.7%, 72.5%, and 59.3% was found for samples with AG1, AG2, and AG3, respectively. Therefore, the waste generated in the steel shot blasting process had the potential to be used in mortar developed to attenuate X-ray radiation.