In order to ensure smooth traffic and driving safety, deicing salt or snow melting agents are usually adopted to solve the problem of traffic jams and prevent pavement surfaces from freezing. The objective of this present study is to investigate the performance deterioration evaluation of asphalt mixture under the chloride salt erosion environment. Five chloride salt solution concentrations were designed and the uniaxial static compression creep test, low-temperature IDT test, freeze-thaw splitting test, and freeze-thaw cycle test were carried out for asphalt mixtures (AC-16) soaked in chloride salt solution. Results showed that with the increase in chloride salt solution concentration, the high-temperature stability, low-temperature crack resistance, and water stability of the asphalt mixture decreases. Moreover, the high-temperature stability, low-temperature crack resistance, and water stability of the asphalt mixture show a decreasing trend under different chloride salt solution concentrations following the negative cubic polynomial function. Based on the viscoelastic analysis, chloride salt solution could reduce the ability of the asphalt mixture to resist instantaneous elastic deformation and permanent deformation, and this influence will become more obvious with the increase in chloride salt solution concentration. In addition, the salt freeze-thaw cycle test indicated that in the early stage of freeze-thaw cycles, the splitting tensile strength of the asphalt mixture decreases rapidly, then tends to be flat, and then decreases rapidly. This study explores the performance damage law of asphalt mixture under salt corrosion, and the analysis results of this study could provide some references for the chloride salt dosage in the snow melting project while spreading deicing salt.