Experimental Chemotherapy of Burns and Shock. VIII. I. Effects of Potassium Administration, of Sodium Loss, and Fluid Loss in Tourniquet Shock

Abstract

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The Energetics of Ion Distribution: The Origin of the Resting Electric Potential of Cells

“…It is difficult to conceive how these fluxes can be equal if they are truly independent, as is required for the derivation of this formulation (35), particularly because the permeability of Cl − is much greater than that of Na + , requiring that J Na in + J K out − J Cl in = 0. In the same Goldman-based analysis, intracellular Cl − was thought to reach electrochemical equilibrium with the potential set by the K + diffusion potential (33) and therefore not to contribute to the resting membrane potential despite its high permeance (36). However, in agreement with other studies (37,38), the data presented here show that in heart the E[Cl − ] o/i of −25 to −35 mV differs markedly from E[K + ] o/i of −85 to −86 mV (Fig.…”

The determination of the redox states and phosphorylation potential in living tissues and their relationship to metabolic control of disease phenotypes

“…Surprising as it may seem, during World War II, it was not recognized that troops suffering burn or hypoxic injuries died from an increase in extracellular K + . This fact was demonstrated by Herbert Tabor [38], the scholarly long time Editor of the Journal of Biological Chemistry , working in the laboratory of Sanford Rosenthal at NIH. His paper was thought so out of the mainstream thinking at the time that it was published in the Public Health Reports , a publication with less than stellar impact scores, but one sponsored by an organization of which NIH was a part.…”