Experimental Clostridial Infections in Dogs

Vincent, James G.; Vincent, Helen Whitgrove; Dowdy, Andrew H.

doi:10.1148/48.6.610

Cited by 1 publication

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“…With the exception of (XV), all the other X I compounds were better inhibitors than the corresponding esters. This was expected as it has been already observed by various workers (Suter, 1941 ;Horsfall, 19453 ;Vincent, 1947) that alkyl and alkoxyl substituents increase fungicidal activity. …”

Section: The Average Percentage Inhibition Of Various Compounds At DIsupporting

confidence: 85%

“…This was expected, as the esters of 4-hydroxybenzoic acid are krfown to be toxic and alkyl substitution generally increases the toxicity (Horsfall, 19453 ;Vincent, 1947).…”

Section: Discussionmentioning

confidence: 99%

“…of these solutions gave the three required concentrations, namely I : 10,000, I : IOO,OOO and I : I,OOO,OOO. Owing to their extremely low solubility the dilutions of mercury derivatives were obtained by weighing the substances directly and then adding requisite volumes of the medium (Vincent, 1947). These compounds were tested at only two concentrations, I : 10,000 and I : IOO,OOO.…”

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Search for organic fungicides : Chemical constitution and fungicidal activity

Sen

Joshi

1952

J Sci Food Agric

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The synthesis of a number of compounds likely to possess fungicidal activity has been described by the authors in the earlier papers of this series (Sen & Joshi, 1948, 1949. This paper incorporates the results of an investigation of the fungicidal action of 55 of those compounds on the fungus Aspergillus niger employing the agar-growth technique. The results have been reviewed with the idea of correlating chemical constitution and fungicidal activity in the light of theories put forward by various authors from time to time. As expected, most of the compounds tested have been found to be considerably toxic to the fungus. Interesting results have been obtained with aryloxyfatty acids, which stimulate growth at lower concentrations.The 55 compounds shown in Table I were tested for. their fungicidal action (contact) on Aspergillus niger. Choice of methodA large number of methods are available for studying the relationship between a substance and its toxicity to fungi. An excellent review of the methods used for the bio-assay of fungicides in the laboratory has been given by Horsfall (1945a, b). The two principal methods available are : (a) the spore-germination test, and (b) the agar-growth method.Of these, the spore-germination test has great advantages over the other test in speed, accuracy and freedom from unwanted organic matter. This method, however, requires a knowledge of such points as spore density and the age of spores, and owing to the limited facilities available in their laboratory, the authors have employed the agar-growth method which is relatively simple. In brief, the technique requires the toxicant to be mixed with the agar medium and the planted fungus is allowed to grow on this poisoned food.The agar'method became quantitative when Falck (1908) showed that the radial growth of a fungus in Petri dishes is linear with time, and that the presence of a toxicant in the agar does not alter the fact.

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Section: The Average Percentage Inhibition Of Various Compounds At DIsupporting

confidence: 85%

“…This was expected, as the esters of 4-hydroxybenzoic acid are krfown to be toxic and alkyl substitution generally increases the toxicity (Horsfall, 19453 ;Vincent, 1947).…”

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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