Experimental cutaneous wound healing in rabbits: using continuous microamperage low-voltage electrical stimulation

Naeini, Aboutorab Tabatabaei; Oryan, Ahmad; Dehghani, S.; Nikahval, Behrooz

doi:10.1007/s00580-008-0724-4

Cited by 12 publications

(11 citation statements)

References 19 publications

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“…There are controversial results from previous studies regarding the effects of ES on the biomechanical properties of healed wounds [30][31]34,[36][37][45][46][47][48]. Although a comparison of the biomechanical properties showed no statistically significant differences between the normalized ultimate strength, stiffness, and strain in the groups, these biomechanical properties tended to be higher in the motor ES group.…”

Section: Groupmentioning

confidence: 43%

Role of sensory and motor intensity of electrical stimulation on fibroblastic growth factor-2 expression, inflammation, vascularization, and mechanical strength of full-thickness wounds

Asadi

Torkaman

Hedayati³

et al. 2013

JRRD

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Abstract-Electrical stimulation (ES) profoundly affects angiogenesis by modulating the production of angiogenic factors. We evaluated the effect of sensory (direct current, 600 microamperes) and motor (monophasic pulse current, 2.5 to 3 milliamperes, 300-microsecond pulse duration, 100 Hz) intensities of cathodal current on the release of fibroblastic growth factor-2 (FGF-2) at the wound site and also the biomechanical and histological properties of healed skin. Ninety-six male, SpragueDawley rats were randomly assigned into one control and two experimental groups. A full-thickness skin incision was made on the dorsal region of each animal. The experimental groups received 10 sessions of ES (sensory or motor) for 1 hour per day every other day. The results showed that FGF-2 levels in the sensory group were significantly greater than in the other groups on the third day. In the motor group, FGF-2 levels were significantly decreased compared with the control group. There were no significant differences between the normalized ultimate strength and stiffness in the groups, but they tended to be higher in the motor ES group. We conclude that the application of sensory ES during the early stage of wound healing may have a beneficial effect on wound healing by inducing the release of angiogenic factors and decreasing the duration of the inflammation phase.

show abstract

Section: Groupmentioning

confidence: 43%

Role of sensory and motor intensity of electrical stimulation on fibroblastic growth factor-2 expression, inflammation, vascularization, and mechanical strength of full-thickness wounds

Asadi

Torkaman

Hedayati³

et al. 2013

JRRD

View full text Add to dashboard Cite

show abstract

“…Although comparisons between some studies have suggested a direct relationship between current intensity and wound closure, other studies have suggested that a higher current intensity could be detrimental and lead to tissue necrosis . Two studies that used the same animal model, polarity and current intensity showed disparate results: one a positive outcome and the other showed no effect on wound closure . This could perhaps be explained by the difference in the number of subjects used.…”

Section: Discussionmentioning

confidence: 99%

“…This could perhaps be explained by the difference in the number of subjects used. Other studies have suggested that reducing the current intensity over time is beneficial as opposed to setting it at a fixed level, and the relationship between current intensity and the size and weight of the animal may also be an important factor …”

Section: Discussionmentioning

confidence: 99%

“…[37][38][39][40] Commencing with either the positive or negative polarity seems to have showed no advantage or disadvantage over the other. 41 Although comparisons between some studies have suggested a direct relationship between current intensity and wound closure, [30][31][32]43 other studies have suggested that a higher current intensity could be detrimental and lead to tissue necrosis. 27 Two studies that used the same animal model, polarity and current intensity showed disparate results: one a positive outcome and the other showed no effect on wound closure.…”

Section: Discussionmentioning

confidence: 99%

“…30 These investigators also found detrimental severe tissue reactions around the electrodes which were implanted into the subcutaneous tissue. 30 Another study 31 showed no benefit of continuous microamperage (100 lA) low voltage ES on wound healing in rabbits that weighed between 1.7 and 2.3 kg, whereas Talebi et al 32 showed an enhancing effect of both anodal and cathodal stimulation at a higher micro-amperage intensity of 600 lA on wound healing in lighter guinea pigs (weighing 0.35-0.4 kg). This further highlighted the importance of the relationship between size and current intensity.…”

Section: Direct Currentmentioning

confidence: 99%

See 2 more Smart Citations

The efficacy of electrical stimulation in experimentally induced cutaneous wounds in animals

Ashrafi

Alonso-Rasgado

Baguneid

et al. 2016

Veterinary Dermatology

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Electrical stimulation has the potential to play a significant role in enhancing cutaneous wound healing in veterinary practice. Clinical studies are necessary to corroborate the findings from experimental studies which have shown promise including the use of alternating pulsed and direct current and the use of bio-electric dressings. The ideal ES device would need to be safe, easy to use, portable, noninvasive and aid wound healing by having a beneficial effect on all wound healing stages.

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The effect of local insulin injection on the healing process of split thickness skin graft donor site: a randomized, double-blind, placebo control clinical trial

et al. 2020

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Experimental cutaneous wound healing in rabbits: using continuous microamperage low-voltage electrical stimulation

Cited by 12 publications

References 19 publications

Role of sensory and motor intensity of electrical stimulation on fibroblastic growth factor-2 expression, inflammation, vascularization, and mechanical strength of full-thickness wounds

Role of sensory and motor intensity of electrical stimulation on fibroblastic growth factor-2 expression, inflammation, vascularization, and mechanical strength of full-thickness wounds

The efficacy of electrical stimulation in experimentally induced cutaneous wounds in animals

The effect of local insulin injection on the healing process of split thickness skin graft donor site: a randomized, double-blind, placebo control clinical trial

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