Experimental Cytomorphological Studies of the Reaction of Mononuclear Phagocyte System in Granulomatosis of Mixed (Silicotic and Tuberculous) Etiology

Abstract

Silicon dioxide in combination with Mycobacterium tuberculosis in BCG vaccine is characterized by a significantly higher granuloma-inducing activity than BCG or silicon dioxide alone. Cell "dissociation" from granulomas is not characteristic of granulomas induced by silicon dioxide or its combination with BCG (in contrast to BCG-induced granulomas). A steady increase in the counts and size, particularly on days 120-180, mainly at the expense of fibroblast accumulation and subtotal fibrosis, are intrinsic to these granulomas. Monocyte retention in the bone marrow is characteristic starting from day 56 until day 180 after injection of both granulomatous factors alone or in combination, particularly so in BCG granulomatosis.

Establishment of rat model of silicotuberculosis and its pathological characteristic

“…The tuberculosis loading in rats was consistent with the progress of silicosis. Interestingly, an in vitro study by Shkurupy et al 13,14 demonstrated that preliminary loading of macrophages with silicium dioxide reduced their antibacterial activity, implying that the cytotoxicity of silica dust to macrophage was the main reason for the damage to the anti-tuberculosis function. However, little was known about the detail injury mechanism and immune regulation.…”

Connective tissue and the problems of its pathological conditions

“…Так, ранее нами было показано, что про-цессы фиброзирования начинают формироваться задолго до развития процессов деструкции как в структурах, которые не принято относить к орга-нам и тканям (туберкулезные гранулемы), так и в паренхиме органов [11][12][13]. На модели генерали-зованного БЦЖ-гранулематоза у мышей призна-ки фиброзирования органов обнаруживали уже на 3-и сут после инфицирования.…”

Silica inflammation modulates lipoperoxide and thi-obarbituric acid reactive substances levels in liver and glucose concentration in blood of alloxan diabetic rats

“…Inflammatory granulomatous diseases are characterized by a high concentration of granulomas in tissue interstitium in which phagocytic cells producing reactive oxy-gen and nitrogen species (RONS) are accumulated [1][2][3]. Because of their high reactivity, free radicals react with unsaturated fatty acids that are components of membrane phospholipids, activate lipid peroxidation processes (LPP), the products of which have a cytotoxic effect [1].…”