Integrated quantum optics promises to enhance the scale and functionality of quantum technologies, and has become a leading platform for the development of complex and stable quantum photonic circuits. Here, we report path-entangled photon-pair generation from two distinct waveguide sources, the manipulation of these pairs, and their resulting high-visibility quantum interference, all on a single photonic chip. Degenerate and non-degenerate photon pairs were created via the spontaneous four-wave mixing process in the silicon-on-insulator waveguides of the device. We manipulated these pairs to exhibit on-chip quantum interference with visibility as high as 100.0 ± 0.4%. Additionally, the device can serve as a two-spatial-mode source of photon-pairs: we measured Hong-Ou-Mandel interference, off-chip, with visibility up to 95 ± 4%. Our results herald the next generation of monolithic quantum photonic circuits with integrated sources, and the new levels of complexity they will offer.