Experimental design of a liposomal lipid system: A potential strategy for paclitaxel-based breast cancer treatment

Paclitaxel-loaded folate-coated long circulating and pH-sensitive liposomes as a potential drug delivery system: A biodistribution study

“…A range of antineoplastic agents is available for clinical applications; however, their low specificity leads to toxic effects in healthy tissues, which, in many cases, could limit their use [1–5]. Among the chemotherapeutic agents, paclitaxel (PTX) is one of the most effective and potent drugs used in the treatment of several solid tumors including, breast, ovarian, non-small cell lung cancer, head and neck tumors [3,6–8]. PTX is poorly soluble in water, therefore, it is commercially available as a micellar dispersion in Cremophor EL ® (polyethoxylated castor oil) and dehydrated ethanol (1:1 v/v), which allows its administration by the intravenous route.…”

“…PTX is poorly soluble in water, therefore, it is commercially available as a micellar dispersion in Cremophor EL ® (polyethoxylated castor oil) and dehydrated ethanol (1:1 v/v), which allows its administration by the intravenous route. Nevertheless, several drawbacks have been related to their clinical application, such as hypersensitivity reactions, peripheral sensory neuropathy, and myelo-suppression, besides development of drug resistance [3,6,9–12]. To overcome these problems, liposomes have emerged as an interesting platform for effective drug delivery since they are biocompatible, bio-degradable and nontoxic nanosystems.…”

“…To overcome these problems, liposomes have emerged as an interesting platform for effective drug delivery since they are biocompatible, bio-degradable and nontoxic nanosystems. In addition, encapsulation into liposomes might prevent drug degradation, improve drug solubility and reduce drug distribution to undesired tissues [3,6,13,14]. Nowadays, some formulations with PTX into different nanosystems have been reported and approved for clinical applications.…”

Technetium-99 m radiolabeled paclitaxel as an imaging probe for breast cancer in vivo

“…PTX is a first-line treatment for patients with metastatic breast cancer. However, PTX is poorly soluble in water, which represents a barrier for intravenous administration [14–16]. The commercially available preparation of PTX, Taxol ® , is a micellar dispersion, composed by a 1:1 blend of Cremophor EL ® (polyethoxylated castor oil) and dehydrated ethanol, which is diluted (5–20 times) in saline or dextrose solution (5%) for in vivo administration [17,18].…”

Stability Indicating Rp-HPLC Method Development and Validation for the Estimation of Paclitaxel in Pharmaceutical Dosage Forms

“…Among them only two stability indicating liquid chromatography methods have reported. Analytical methods for Paclitaxel includes, Stability indicating HPLC method (7,8), Assay method (9-12), Bioanalytical method (13)(14)(15)(16)(17)(18), bio-analytical with other drug (19), UV-Spectrophotometer (20), UV-derivative Spectrophotometer (21). Now it is a challenging task to develop a RP-HPLC method is simpler in terms of mobile phase wide linearity range with a good correlation coefficient value, high precise, rapid and economic stability indicating method for estimating Paclitaxel commercial formulations.…”