2013
DOI: 10.1016/j.jct.2012.07.017
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Experimental determination and thermodynamic modeling of phase equilibrium and protein partitioning in aqueous two-phase systems containing biodegradable salts

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Cited by 34 publications
(21 citation statements)
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“…From the table it is clear that the EEV values follow the order citrate > tartrate > succinate, and this reveals that citrate anion has the higher valency than others and has the highest salting-out ability. Similar results were observed by Perez et al [17]. Moreover this is in agreement with the familiar Hofmeister series [27] for anions which follows the order: citrate > tartrate > succinate.…”
Section: Resultssupporting
confidence: 92%
See 1 more Smart Citation
“…From the table it is clear that the EEV values follow the order citrate > tartrate > succinate, and this reveals that citrate anion has the higher valency than others and has the highest salting-out ability. Similar results were observed by Perez et al [17]. Moreover this is in agreement with the familiar Hofmeister series [27] for anions which follows the order: citrate > tartrate > succinate.…”
Section: Resultssupporting
confidence: 92%
“…According to our knowledge there are only three [1517] reports available for PEG + succinate + water system. Ananthapadmanabhan and Goddard [15] reported binodal data for PEG 6000 + succinate + water at room temperature; Zafarani-Moattar and Hamzehzadeh [16] reported the binodal data and tie-line compositions of PEG 6000 + succinate + water at 298.15 K; Perez et al [17] studied the binodal behavior of PEG 6000 + succinate + water at 295.1 K and partitioning of various standard proteins. However, the data for other temperatures for these systems are not available in the literature.…”
Section: Introductionmentioning
confidence: 99%
“…Surface properties of materials and components of ATPS determine the partitioning between two phases [7]. Poorly understood partition behavior is a major barrier in widely adaptation of ATPS on commercial levels for the purification of biomolecules [25]. …”
Section: Two-phase Formation Thermodynamics and Partitioningmentioning
confidence: 99%
“…AB is the concentration of A in the bottom phase at equilibrium [26]. So far, different models have been devised by the researchers to understand the partitioning in ATPS [25, 2832]. There is no good comprehensive theory of liquid and liquid mixtures.…”
Section: Two-phase Formation Thermodynamics and Partitioningmentioning
confidence: 99%
“…Significant progress has been made in the theoretical understanding of the underlying mechanisms of protein partitioning as well as phase equilibrium in ATPS. For the latter, several thermodynamic models have been successfully implemented for systems containing polymers (Wu et al, 1998), salts (Perez et al, 2013) and ILs (Simoni et al, 2008). Thermodynamic models have also been used to describe and predict the partition coefficients of model proteins in ATPS; satisfactory estimations are reported for polymer/salt systems using an extension of the Pitzer's model (Perez et al, 2013) and multicomponent Wilson model (Madeira and Xu, 2005).…”
Section: Introductionmentioning
confidence: 99%