Experimental Determination of Cardiotoxicity of Cadmium Salts and Trace Elements Citrates

Шаторна, В. Ф.; Garets, V. I.; Kononova, I. I.; Halperin, О. І.

doi:10.29254/2077-4214-2020-3-157-62-65

Cited by 4 publications

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“…Зі зростанням урбанізації визначається ускладнення екологічної ситуації як на транспортних магістралях та площах, які зайняті промисловими підприємствами, але і на прилеглих до них територіях. Важкі метали та їх сполуки поступають з повітря до водних резервів та ґрунтів, тобто включаються в екологічну систему регіону і стають однією з пріоритетних груп токсикантів, що мають як локальне, регіональне так і глобальне поширення [1,2,3]. Результати численних досліджень підтверджують, що однією з етіопатогенетичних причин неінфекційних хвороб є вплив екологічних факторів: викиди промислових підприємств і автотранспорту, радіаційне забруднення, хімізація сільського господарства та ін.…”

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“…Основними джерелами надходження в організм людини хімічного фактору є харчові продукти, питна вода, атмосферне повітря. Токсична дія хімічних елементів пов'язана з їхньою всмоктуваністю у шлунково-кишковому тракті, яка залежить від форми та ступеню розчинності елементів [3,4]. Токсичність важких металів залежить від концентрації, тривалості дії, Актуальні проблеми сучасної медицини температури, насиченості води киснем та багатьох інших чинників.…”

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The Effect of Cronic Isolated Administration of Cadmium Chloride on the Morphological Structures in the Walls of Small Intestine of Pregnant Female Rats

Shatorna,

Tymchuk

2023

Act. Probl. of the Modern Med.

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In recent years, the anthropopolitical environmental polluntion with heavy metals has become one of the main threats to living organisms, including humans, and economic and technological progress is increasingly resulting in the disruption of natural ecosystems. Heavy metals include more than forty chemical elements of the periodic table, including chromium, cadmium, manganese, mercury, iron, cobalt, nickel, and others. They are often used in industry and are part of herbicides, insecticides, and medicines. In excessive quantities, they can change the structure of proteins, negatively affect metabolism, lead to cellular mutations, disrupt the structure and permeability of cell membranes, and cause malfunctioning of internal organs. Today, it is important to determine the impact of heavy metal compounds on the body in case of their constant (chronic) intake and accumulation in the body. The purpose of this study was to determine morphological changes in the structure of the walls in the small intestine of rats subjected to the chronic isolated exposure to cadmium salts in a dose of 2.0 mg/kg (enteral administration). The study involved 32 young female Wistar rats, with weights ranging from 180 to 300 g. Female rats with confirmed pregnancies were divided into the following groups: the first group served as the control, and the second group underwent isolated injection of cadmium chloride solution at a dose of 2.0 mg/kg. The results of the experimental daily intragastric long-term administration of cadmium chloride showed morphological changes in the structure of the small intestine in rats. The analysis of the data obtained showed that exposure to cadmium chloride in a dose of 2.0 mg/kg leads to a significant thinning of the villi of the small intestine and mucous membrane compared to the control. When exposed to cadmium chloride in the specified dose, the number of goblet cells in the mucous membrane of the small intestine villi increased at both periods of the study, which indicates an increase in the protective function of the small intestinal mucosa against the action of a negative factor. Under the influence of cadmium, the narrowing of the outer and inner diameters of the crypt was also determined that is confirmed by the calculation of the index of the diameter of the small intestine crypt.

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The Effect of Cronic Isolated Administration of Cadmium Chloride on the Morphological Structures in the Walls of Small Intestine of Pregnant Female Rats

Shatorna,

Tymchuk

2023

Act. Probl. of the Modern Med.

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Dynamics of Cadmium Accumulation in the Blood and Small Intestine in a Chronic Experiment on Rats

Шаторна

Tymchuk

2023

VPBM

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Morphological Changes in the Structure of the Small Intestine Wall of Pregnant Female Rats Under the Influence of Chronic Administration of Cadmium Chloride and Copper Succinate

Shatorna,

Tymchuk

2023

VPBM

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Вісник проблем біології і медицини -2023 -Вип. 4 (171) / Bulletin of problems in biology and medicine -2023 -Issue 4 (171) 116 БІОЛОГІЯ / BIOLOGY comparison of the obtained results of the experiment proved the modifying effect of copper and zinc succinates on the degree of cadmium accumulation in embryos and hearts of adult females when they were simultaneously administered in an experiment on rats.

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Experimental Determination of Cardiotoxicity of Cadmium Salts and Trace Elements Citrates

Cited by 4 publications

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The Effect of Cronic Isolated Administration of Cadmium Chloride on the Morphological Structures in the Walls of Small Intestine of Pregnant Female Rats

The Effect of Cronic Isolated Administration of Cadmium Chloride on the Morphological Structures in the Walls of Small Intestine of Pregnant Female Rats

Dynamics of Cadmium Accumulation in the Blood and Small Intestine in a Chronic Experiment on Rats

Morphological Changes in the Structure of the Small Intestine Wall of Pregnant Female Rats Under the Influence of Chronic Administration of Cadmium Chloride and Copper Succinate

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