The formation of local areas in large buildings with regulated thermal conditions is an urgent task. The use of gas infrared heaters for this purpose raises questions on the utility of an air-exchange system and the monitoring of the combustion product concentration. In this study, the modeling of heat transfer processes on premises with a gas infrared heater and an air-exchange system was conducted. The carbon dioxide concentration in the local working area when using a light-type gas infrared heater was determined. The regularities of current formation for circulating air and combustion products on the premises at various air-exchange rates were analyzed. The profiles of CO2 temperatures and concentrations in the local working areas on the left and right of the equipment model are shown. The article makes a conclusion about the influence of air velocity from the air-exchange system based on average values of carbon dioxide concentration on the premises and in the local working area. The possibility of increasing the temperature in the local working area without exceeding the permissible CO2 concentrations (less than 1000 ppm) has been identified. The formulated approach allows us to predict the available modes of the air-exchange system to create the highest possible comfort heating parameters while maintaining an acceptable degree of air pollution from combustion products.