Experimental determination of the gadolinium dose enhancement in phantom irradiated with low energy X-ray sources by a spectrophotometer -Gafchromic-EBT3 dosimetry system

Santibáñez, M.; Fuentealba, M.; Torres, Flavio; Vargas, Asticio

doi:10.1016/j.apradiso.2019.108857

Cited by 7 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The selected n parameter satisfied all of the fit tests and was found to produce an acceptable combined standard uncertainty (k = 1.0; <5.00% of radiotherapy accuracy) [74]. Most film dosimetry studies have investigated the ability of high-Z contrast materials or metallic NPs to induce DE in both monochromatic and polychromatic low-energy photon beams (the majority of which use a single type of NPs) [75][76][77][78]. The presence of NP-loaded solution in the dosimeter's environment resulted in an increase in absorbed dose.…”

Section: Discussionmentioning

confidence: 95%

Gafchromic™ EBT3 Film Measurements of Dose Enhancement Effects by Metallic Nanoparticles for 192Ir Brachytherapy, Proton, Photon and Electron Radiotherapy

et al. 2022

View full text Add to dashboard Cite

Interest in combining metallic nanoparticles, such as iron (SPIONs), gold (AuNPs) and bismuth oxide (BiONPs), with radiotherapy has increased due to the promising therapeutic advantages. While the underlying physical mechanisms of NP-enhanced radiotherapy have been extensively explored, only a few research works were motivated to quantify its contribution in an experimental dosimetry setting. This work aims to explore the feasibility of radiochromic films to measure the physical dose enhancement (DE) caused by the release of secondary electrons and photons during NP–radiotherapy interactions. A 10 mM each of SPIONs, AuNPs or BiONPs was loaded into zipper bags packed with GAFCHROMIC™ EBT3 films. The samples were exposed to a single radiation dose of 4.0 Gy with clinically relevant beams. Scanning was conducted using a flatbed scanner in red-component analysis for optimum sensitivity. Experimental dose enhancement factors (DEFExperimental) were then calculated using the ratio of absorbed doses (with/without NPs) converted from the films’ calibration curves. DEFExperimental for all NPs showed no significant physical DE beyond the uncertainty limits (p > 0.05). These results suggest that SPIONs, AuNPs and BiONPs might potentially enhance the dose in these clinical beams. However, changes in NPs concentration, as well as dosimeter sensitivity, are important to produce observable impact.

show abstract

Section: Discussionmentioning

confidence: 95%

Gafchromic™ EBT3 Film Measurements of Dose Enhancement Effects by Metallic Nanoparticles for 192Ir Brachytherapy, Proton, Photon and Electron Radiotherapy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…On the other hand, experimental quantification still presents important challenges, the main difficulty being the ability to record the contribution of low-energy photoelectrons and Auger electrons, which do not manage to pass through the walls that cover traditional dosimeters and be recorded by the radiosensitive region. Dose enhancement measurements obtained through Gafchromic model EBT2 and EBT3 radiochromic films (specially designed for “External Beam Therapy (EBT)” and commercially known as EBT2 and EBT3 films) have already been reported some years ago [ 39 , 40 , 41 , 42 , 43 ]. The EBT3 film possesses a 30

m radiosensitive substrate placed between two 125

m transparent polyester films, barriers not penetrable by electrons with energies <90 keV, making it difficult to directly measure the DEF for energy beams close to the Gd absorption edge.…”

Section: Introductionmentioning

confidence: 99%

An Optimized Method for Evaluating the Potential Gd-Nanoparticle Dose Enhancement Produced by Electronic Brachytherapy

Fuentealba,

Ferreira,

Salgado

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

This work reports an optimized method to experimentally quantify the Gd-nanoparticle dose enhancement generated by electronic brachytherapy. The dose enhancement was evaluated considering energy beams of 50 kVp and 70 kVp, determining the Gd-nanoparticle concentration ranges that would optimize the process for each energy. The evaluation was performed using delaminated radiochromic films and a Poly(methyl methacrylate) (PMMA) phantom covered on one side by a thin 2.5 μm Mylar filter acting as an interface between the region with Gd suspension and the radiosensitive film substrate. The results for the 70 kVp beam quality showed dose increments of 6±6%, 22±7%, and 9±7% at different concentrations of 10, 20, and 30 mg/mL, respectively, verifying the competitive mechanisms of enhancement and attenuation. For the 50 kVp beam quality, no increase in dose was recorded for the concentrations studied, indicating that the major contribution to enhancement is from the K-edge interaction. In order to separate the contributions of attenuation and enhancement to the total dose, measurements were replicated with a 12 μm Mylar filter, obtaining a dose enhancement attributable to the K-edge of 29±7% and 34±7% at 20 and 30 mg/mL, respectively, evidencing a significant additional dose proportional to the Gd concentration.

show abstract

Potentials of Bismuth-Based Nanoparticles and Baicalein Natural Compounds as Radiosensitizers in Cancer Radiotherapy: a Review

Sisin

Rahman

2023

BioNanoSci.

View full text Add to dashboard Cite

Experimental determination of the gadolinium dose enhancement in phantom irradiated with low energy X-ray sources by a spectrophotometer -Gafchromic-EBT3 dosimetry system

Cited by 7 publications

References 29 publications

Gafchromic™ EBT3 Film Measurements of Dose Enhancement Effects by Metallic Nanoparticles for 192Ir Brachytherapy, Proton, Photon and Electron Radiotherapy

Gafchromic™ EBT3 Film Measurements of Dose Enhancement Effects by Metallic Nanoparticles for 192Ir Brachytherapy, Proton, Photon and Electron Radiotherapy

An Optimized Method for Evaluating the Potential Gd-Nanoparticle Dose Enhancement Produced by Electronic Brachytherapy

Potentials of Bismuth-Based Nanoparticles and Baicalein Natural Compounds as Radiosensitizers in Cancer Radiotherapy: a Review

Contact Info

Product

Resources

About