2012
DOI: 10.1186/1752-153x-6-138
|View full text |Cite
|
Sign up to set email alerts
|

Experimental determination of the oral bioavailability and bioaccessibility of lead particles

Abstract: In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibili… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
45
0
2

Year Published

2014
2014
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 75 publications
(48 citation statements)
references
References 122 publications
(339 reference statements)
1
45
0
2
Order By: Relevance
“…Environmental inputs, including aerosol deposition, may thus be a major source of Pb in human hair, as discussed by Anand et al [51] who indicated a possible human uptake of elements from the aerosols, especially Al, Zn, Pb and Cu. It is also known that children are more prone to ingest dust particles from toys lying on the floor of an old house, and these can accumulate Pb-rich small particles deriving from wall old paint [52]. Nevertheless, the aerosol hypothesis seems to be supported by the fact that the 206 Pb/ 204 Pb variations observed prior to moving to Canada are comparable to the ratios measured in particulate matter emissions (PM 10 ) in France [53,54].…”
Section: Resultsmentioning
confidence: 90%
“…Environmental inputs, including aerosol deposition, may thus be a major source of Pb in human hair, as discussed by Anand et al [51] who indicated a possible human uptake of elements from the aerosols, especially Al, Zn, Pb and Cu. It is also known that children are more prone to ingest dust particles from toys lying on the floor of an old house, and these can accumulate Pb-rich small particles deriving from wall old paint [52]. Nevertheless, the aerosol hypothesis seems to be supported by the fact that the 206 Pb/ 204 Pb variations observed prior to moving to Canada are comparable to the ratios measured in particulate matter emissions (PM 10 ) in France [53,54].…”
Section: Resultsmentioning
confidence: 90%
“…However, in order to examine pharmacokinetic release from PM 10 in bodily fluids, in vitro bioassays are employed. These offer highly reproducible, rapid, and inexpensive evaluation of metal(loid) bioaccessibility (Deshommes et al, 2012), which is defined as the fraction of total solid phase contaminant concentration released into a biofluid simulant in a given time frame. The bioaccessible fraction is, therefore, an estimate of the contaminant fraction available for interaction with a target organ (the actual in vivo value of which distinguishes the bioavailable fraction).…”
Section: Introductionmentioning
confidence: 99%
“…However, recent scientific findings on water supply system indicated that lead (Pb) is the significant contaminant of emerging concern whose toxic exposure occurs through drinking water [8][9][10]. Meanwhile, Sharrett et al [31] and Edwards [32] found that in USA the low concentration of Pb in drinking water in the long run would lead to chronic diseases and fatal deaths as well as Pb contamination in drinking water was not only recorded in urban areas but also in rural areas.…”
Section: Human Health Risk Of Pb Ingestionmentioning
confidence: 99%
“…In the meantime, a few studies at LRBM determined the higher concentrations of Pb [6,7] in the supply water mostly because of its contamination in the water distribution pipeline. Moreover, many studies have considered Pb as an emerging contaminant and its ingestion is an issue of emerging concern [8][9][10][11]. However, there is no study which determined the dissolved Pb status in the treated water at the outlets of WTPs as well as the concentration differences between treated water at WTPs and supply water at household level.…”
Section: Introductionmentioning
confidence: 99%