Experimental development of cardiac transplantation.

The article is devoted to the outstanding Soviet scientist, the head of the department of pharmacology of the Gorky Medical Institute (now the Nizhny Novgorod Medical Academy), the honored worker of science, professor N.P. Sinitsyn (1900–1972). His achievements in surgery, physiology, experimental transplantology and experimental cardiac surgery have studied. It is shown that in 1937–1943. N.P. Sinitsyn was ﬁ rst man in the world carried out successful transplantations of an additional and isolated heart to frogs in the thoracic cavity and for the ﬁ rst time in Russia transplanted the dog’s head; in 1940–1955 (with interruptions) he conducted experiments on transplantation of the additional heart in the chest to dogs; in 1955–1956 he invented a way of visual control of cardiac activity of the biological and donor heart per se; in 1956 a model of a «two-headed» frog was created, and in 1959–1979 he conducted experiments on modeling and resection of heart aneurysms, plastic of the ventricles of the heart, stimulation of myocardial regeneration by electric current, studied regeneration of cardiac and papillary muscles. The reasons for not allowing the results of these experiments to go beyond the physiological laboratory are discussed in this article.

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Section: пересадка сердца холоднокровным (черепахе)unclassified

Professor Nikolai Petrovich Sinitsyn (1900–1972) – surgeon, physiologist, experimental transplantologist and cardiac surgeon (to the 50th anniversary of the ﬁ rst heart transplantation to a man)

Черемисова

Кордзая

Глянцев

2018

RJTAO

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“…He performed and end-to-side anastomosis of the donor aorta, pulmonary artery and venae cavae to the corresponding recipient vessels and reattached the pulmonary veins to the recipients left atrium and closed off with a purse strings. He reported survival times of up to 15.5 h, thereby creating the first model of an orthotopic heart transplant providing the entirety of the pumping function [37] . Demikhov's research was not published in English until 1962. Interest in Frank C Mann's work was rekindled in 1951.…”

Section: History Of Cardiac Surgery and Transplantationmentioning

confidence: 99%

Heart transplantation: a history lesson of Lazarus

Singh¹,

Banner²,

Al‐Attar³

2018

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One of the notable advances in modern day medicine is organ transplantation. None more so than the heart. A complex interaction between physiology, surgery and immunology that spanned decades, involving the hard work of many pioneers in their fields. We revisit the contributions of the pioneers as well as marvel at the paradigm shifts in medicine that have made heart transplantation safe and reproducible with in excess of 3000 transplants done yearly today.

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“…I interspersed my surgical training with 3 yr in full‐time research at the Institute of Cardiology at the National Heart Hospital, working on aspects of heart [1] and heart–lung Tx [2] and donor heart resuscitation and storage [3,4]. During this period, I was fortunate to be present at the first heart transplant performed in the UK (by Donald Ross at the National Heart Hospital) on May 3, 1968, the world’s 11th such transplant [5].…”

Section: Cambridgementioning

confidence: 99%

Outwitting evolution*

Cooper¹

2010

Xenotransplantation

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The author pays tribute to those who stimulated him to follow a career in clinical cardiothoracic surgery and experimental transplantation. Highlights of his career have been in contributing to (i) the first hypothermic perfusion storage of the donor heart to be used successfully in clinical practice, (ii) hormonal therapy in the management of the brain-dead potential organ donor, (iii) the identification of Gal alpha 1,3Gal as the major antigenic target for primate natural anti-pig antibodies, (iv) the 2- to 6-month survival of alpha1,3-galactosyltransferase gene-knockout hearts transplanted into baboons, and (v) the 3- to 12-month normoglycemia following the transplantation of islets from CD46-transgenic pigs into diabetic monkeys. Many friends have been made through a mutual interest in transplantation, particularly through the activities of the International Xenotransplantation Association (IXA). The author thanks the many mentors, colleagues, and research fellows with whom it has been his great privilege and pleasure to work during the past several decades, and readily acknowledges that it is largely their contributions that have enabled him to receive the honor of Honorary Membership of the IXA.

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Experimental development of cardiac transplantation.

Cited by 41 publications

References 66 publications

Professor Nikolai Petrovich Sinitsyn (1900–1972) – surgeon, physiologist, experimental transplantologist and cardiac surgeon (to the 50th anniversary of the ﬁ rst heart transplantation to a man)

Professor Nikolai Petrovich Sinitsyn (1900–1972) – surgeon, physiologist, experimental transplantologist and cardiac surgeon (to the 50th anniversary of the ﬁ rst heart transplantation to a man)

Heart transplantation: a history lesson of Lazarus

Outwitting evolution*

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