Experimental epileptogenesis: Kindling-induced epilepsy in rats

Pinel, John P. J.; Rovner, Louis I.

doi:10.1016/0014-4886(78)90133-4

Cited by 303 publications

(144 citation statements)

References 10 publications

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“…In addition, cases of TLE with frequent interietal spikes tend to be more severe than cases with infrequent interietal spikes (Rosati et al, 2003). In support of this, interietal diseharge frequeney tends to positively eorrelate to the number of kindling trials administered in rats (Pinel and Rovner, 1978). However, others have observed that, in general, interietal spike frequeney does not change immediately prior to seizure onset in patients aeeording to sorne (Gotman, 1991;Katz et al, 1991), or deereases preeeding seizures aeeording to others (Lange et al, 1983;de Curtis and Avanzini, 2001), and inereases immediately following ietal diseharges (Gotman and Mareiani, 1985;Gotman, 1991 ln eonvulsant-treated sliees, the pieture is also mixed.…”

Section: General Findings: Ln Vitro Epileptiform Activitymentioning

confidence: 76%

Epileptiform synchronization in the rat insular and perirhinal cortices in vitro

Sudbury

Avoli

2007

Eur J of Neuroscience

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The hippocampus plays a primary role in temporal lobe epilepsy, a common form of partial epilepsy in adults. Recent studies, however, indicate that extrahippocampal areas such as the perirhinal and insular cortices represent important participants in this epileptic disorder. By employing field potential recordings in the in vitro 4‐aminopyridine model of temporal lobe epilepsy, we have investigated here the contribution of glutamatergic and GABAergic signaling to epileptiform activity in these structures. First, we provide evidence of epileptiform synchronicity between the perirhinal and insular cortices, and resolve some pharmacological and network mechanisms involved in sustaining the interictal‐ and ictal‐like discharges recorded there. Second, we report that in the absence of ionotropic glutamatergic transmission, GABAergic networks produce synchronous potentials that spread between the perirhinal and insular cortices. Finally, we have established that such activity is modulated by activating µ‐opioid receptors. Our findings support clinical and experimental evidence concerning the involvement of the perirhinal and insular cortex networks in temporal lobe epilepsy, and provide observations that may impact research focussing on the role of the insular cortex in nociception.

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Section: General Findings: Ln Vitro Epileptiform Activitymentioning

confidence: 76%

Epileptiform synchronization in the rat insular and perirhinal cortices in vitro

Sudbury

Avoli

2007

Eur J of Neuroscience

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“…Frequently used animal models of TLE are the kindling model (Goddard, 1967;McNamara, 1986;Pinel and Rovner, 1978) where repetitive daily stimulation eventually leads to the emergence of spontaneous recurrent seizures (SRS); and the kainate (BenAri et al, 1980;Cavalheiro et al, 1982;Hellier et al, 1998) or the pilocarpine models (Leite et al, 1990;Turski et al, 1983) where administration of a chemical agent leads to an intense and lasting epileptic seizure (status epilepticus, SE) followed by SRS after a few weeks. Seizures in rodents also can be induced by domoic acid, another chemical agent acting on glutamate/kainate receptors (Doucette et al, 2004;Tasker et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Modeling epileptogenesis and temporal lobe epilepsy in a non-human primate

et al. 2011

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“…These late drops-which occurred in 67% of subjects-account for the slight downward shift seen in the late phases of the group cuwe. These 'late" changes in AD threshold -if they also take place in the threshold for non-triggered events -may relate to the spontaneous seizures which are seen in the kindling preparation after several hundred stimulations (Pinel and Rovner, 1978). Kindling-induced changes are progressive, and do not stop with the first stage 5 seizure.…”

Section: Methodsmentioning

confidence: 99%