Experimental evaluation of antipyretic and analgesic activity of aspartame

Pradhan, Sapna; Uh, Shah; Mathur, Archana; Sharma, S.

doi:10.4103/0253-7613.75683

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…Aspartyl-phenylalanine (aspartame), a low-calorie sweetener, is directly connected to xanthine in the network. Aspartame was shown to pose antipyretic, analgesic and anti-inflammatory action and to delay osteoarthritis in animal models (LaBuda and Fuchs 2001 ; Manion et al 2011 ; Pradhan et al 2011 ). Interference of aspartame with rheumatoid factor activity has been proposed to alleviate the pain and immobility resulting from chronic inflammation of joints (Ramsland et al 1999 ).…”

Section: Resultsmentioning

confidence: 99%

Metabolite profiling reveals new insights into the regulation of serum urate in humans

et al. 2013

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Serum urate, the final breakdown product of purine metabolism, is causally involved in the pathogenesis of gout, and implicated in cardiovascular disease and type 2 diabetes. Serum urate levels highly differ between men and women; however the underlying biological processes in its regulation are still not completely understood and are assumed to result from a complex interplay between genetic, environmental and lifestyle factors. In order to describe the metabolic vicinity of serum urate, we analyzed 355 metabolites in 1,764 individuals of the population-based KORA F4 study and constructed a metabolite network around serum urate using Gaussian Graphical Modeling in a hypothesis-free approach. We subsequently investigated the effect of sex and urate lowering medication on all 38 metabolites assigned to the network. Within the resulting network three main clusters could be detected around urate, including the well-known pathway of purine metabolism, as well as several dipeptides, a group of essential amino acids, and a group of steroids. Of the 38 assigned metabolites, 25 showed strong differences between sexes. Association with uricostatic medication intake was not only confined to purine metabolism but seen for seven metabolites within the network. Our findings highlight pathways that are important in the regulation of serum urate and suggest that dipeptides, amino acids, and steroid hormones are playing a role in its regulation. The findings might have an impact on the development of specific targets in the treatment and prevention of hyperuricemia.Electronic supplementary materialThe online version of this article (doi:10.1007/s11306-013-0565-2) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Metabolite profiling reveals new insights into the regulation of serum urate in humans

et al. 2013

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“…[20] Some animal studies have shown that aspartame poses antipyretic, analgesic and anti-inflammatory action. [21,22] Interference of aspartame with rheumatoid factor activity has been proposed to alleviate the pain and immobility resulting from chronic infl ammation of joints. [23] are born with an inherited condition called "phenylketonuria" (PKU).…”

Section: Aspartamementioning

confidence: 99%

Sugar substitutes: Health controversy over perceived benefits

Tandel

2011

Journal of Pharmacology and Pharmacotherapeutics

198

130

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Sugar is an inseparable part of the food we consume. But too much sugar is not ideal for our teeth and waistline. There have been some controversial suggestions that excessive sugar may play an important role in certain degenerative diseases. So artificial sweeteners or artificially sweetened products continue to attract consumers. A sugar substitute (artificial sweetener) is a food additive that duplicates the effect of sugar in taste, but usually has less food energy. Besides its benefits, animal studies have convincingly proven that artificial sweeteners cause weight gain, brain tumors, bladder cancer and many other health hazards. Some kind of health related side effects including carcinogenicity are also noted in humans. A large number of studies have been carried out on these substances with conclusions ranging from “safe under all conditions” to “unsafe at any dose”. Scientists are divided in their views on the issue of artificial sweetener safety. In scientific as well as in lay publications, supporting studies are often widely referenced while the opposing results are de-emphasized or dismissed. So this review aims to explore the health controversy over perceived benefits of sugar substitutes.

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“…Obesity and its related spectrum of metabolic disorders have emerged as a global health epidemic in recent decades. It is widely believed that several risk factors, such as high-sugar diet or high-fat diet, partly contribute to the increasing occurrence of obesity and its related health problems, including type 2 diabetes, fatty liver disease, cardiovascular disease, and hypertension [1]. Non-nutritive sweeteners (NNSs) are increasingly used to replace traditional caloric sugars to reduce energy intake while maintaining tasting flavor in foods and beverages.…”

Section: Introductionmentioning

confidence: 99%

Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans

Wang

Lam

et al. 2021

Antioxidants

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Non-nutritive sweeteners are widely used in food and medicines to reduce energy content without compromising flavor. Herein, we report that Rebaudioside A (Reb A), a natural, non-nutritive sweetener, can extend both the lifespan and healthspan of C. elegans. The beneficial effects of Reb A were principally mediated via reducing the level of cellular reactive oxygen species (ROS) in response to oxidative stress and attenuating neutral lipid accumulation with aging. Transcriptomics analysis presented maximum differential expression of genes along the target of rapamycin (TOR) signaling pathway, which was further confirmed by quantitative real-time PCR (qPCR); while lipidomics uncovered concomitant reductions in the levels of phosphatidic acids (PAs), phosphatidylinositols (PIs) and lysophosphatidylcholines (LPCs) in worms treated with Reb A. Our results suggest that Reb A attenuates aging by acting as effective cellular antioxidants and also in lowering the ectopic accumulation of neutral lipids.

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Experimental evaluation of antipyretic and analgesic activity of aspartame

Cited by 7 publications

References 5 publications

Metabolite profiling reveals new insights into the regulation of serum urate in humans

Metabolite profiling reveals new insights into the regulation of serum urate in humans

Sugar substitutes: Health controversy over perceived benefits

Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans

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