Experimental evaluation of cMUT and PZT transducers in receive only mode for photoacoustic imaging

Warshavski, Omri; Meynier, Cyril; Senegond, Nicolas; Chatain, Pascal; Rebling, Johannes; Razansky, Daniel; Felix, N.; An, Ning

doi:10.1117/12.2211799

Cited by 10 publications

(8 citation statements)

References 11 publications

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“…We fully characterized the instrument and validated using tissue-mimicking phantoms, in vivo mouse models of PCa, ex vivo intact human prostates, and in vivo human prostate transrectal imaging (n = 20), including first-in-man contrast-enhanced prostate imaging using intravenous administration of the U.S. Food and Drug Administration (FDA)-approved indocyanine green (ICG) contrast agent (n = 10). Compared to the wide use of piezoelectric transducers in conventional US imaging, our CMUTs are designed and fabricated in-house using microelectromechanical systems (29,30), and offer advantages such as wide bandwidth, improved signal-to-noise ratio (SNR) due to direct or proximal bonding with application-specific integrated circuits (ASICs), ease of fabricating large 1D (linear) as well as 2D arrays with 500 m thickness (31)(32)(33)(34)(35)(36), and high PA depth sensitivity (37).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous transrectal ultrasound and photoacoustic human prostate imaging

et al. 2019

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Imaging technologies that simultaneously provide anatomical, functional, and molecular information are emerging as an attractive choice for disease screening and management. Since the 1980s, transrectal ultrasound (TRUS) has been routinely used to visualize prostatic anatomy and guide needle biopsy, despite limited specificity. Photoacoustic imaging (PAI) provides functional and molecular information at ultrasonic resolution based on optical absorption. Combining the strengths of TRUS and PAI approaches, we report the development and bench-to-bedside translation of an integrated TRUS and photoacoustic (TRUSPA) device. TRUSPA uses a miniaturized capacitive micromachined ultrasonic transducer array for simultaneous imaging of anatomical and molecular optical contrasts [intrinsic: hemoglobin; extrinsic: intravenous indocyanine green (ICG)] of the human prostate. Hemoglobin absorption mapped vascularity of the prostate and surroundings, whereas ICG absorption enhanced the intraprostatic photoacoustic contrast. Future work using the TRUSPA device for biomarker-specific molecular imaging may enable a fundamentally new approach to prostate cancer diagnosis, prognostication, and therapeutic monitoring.

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Section: Introductionmentioning

confidence: 99%

Simultaneous transrectal ultrasound and photoacoustic human prostate imaging

et al. 2019

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“…However, the current literature lacks information on the potential performance increase achievable by using CMUT technology in place of classical PZT technology. Only recently, a RX-mode operation performance comparison between a PZT linear probe and an equivalent CMUT probe was carried out [17] , [18] , and the benefits achievable by the higher sensitivity and the wider acceptance angle of the CMUT probe were discussed in a PA imaging application context.…”

Section: Introductionmentioning

confidence: 99%

Quantitative comparison of PZT and CMUT probes for photoacoustic imaging: Experimental validation

et al. 2017

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Photoacoustic (PA) signals are short ultrasound (US) pulses typically characterized by a single-cycle shape, often referred to as N-shape. The spectral content of such wideband signals ranges from a few hundred kilohertz to several tens of megahertz. Typical reception frequency responses of classical piezoelectric US imaging transducers, based on PZT technology, are not sufficiently broadband to fully preserve the entire information contained in PA signals, which are then filtered, thus limiting PA imaging performance. Capacitive micromachined ultrasonic transducers (CMUT) are rapidly emerging as a valid alternative to conventional PZT transducers in several medical ultrasound imaging applications. As compared to PZT transducers, CMUTs exhibit both higher sensitivity and significantly broader frequency response in reception, making their use attractive in PA imaging applications. This paper explores the advantages of the CMUT larger bandwidth in PA imaging by carrying out an experimental comparative study using various CMUT and PZT probes from different research laboratories and manufacturers. PA acquisitions are performed on a suture wire and on several home-made bimodal phantoms with both PZT and CMUT probes. Three criteria, based on the evaluation of pure receive impulse response, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) respectively, have been used for a quantitative comparison of imaging results. The measured fractional bandwidths of the CMUT arrays are larger compared to PZT probes. Moreover, both SNR and CNR are enhanced by at least 6 dB with CMUT technology. This work highlights the potential of CMUT technology for PA imaging through qualitative and quantitative parameters.

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“…The CMUT probe has a wider bandwidth than PZT [86] and achieves higher acceptance angle due to the low directivity. The CMUT probe can be easily integrated with microelectronic circuits due to the easy microlevel fabrication [87]. Oeri et al used CMUT arrays of 15 MHz bandwidth to image finger for detecting inflammatory arthritis [49].…”

Section: Current Issues and Future Outlooksmentioning

confidence: 99%

Clinical photoacoustic imaging platforms

et al. 2018

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Photoacoustic imaging (PAI) is a new promising medical imaging technology available for diagnosing and assessing various pathologies. PAI complements existing imaging modalities by providing information not currently available for diagnosing, e.g., oxygenation level of the underlying tissue. Currently, researchers are translating PAI from benchside to bedside to make unique clinical advantages of PAI available for patient care. The requirements for a successful clinical PAI system are; deeper imaging depth, wider field of view, and faster scan time than the laboratory-level PAI systems. Currently, many research groups and companies are developing novel technologies for data acquisition/signal processing systems, detector geometry, and an acoustic sensor. In this review, we summarize state-of-the-art clinical PAI systems with three types of the imaging transducers: linear array transducer, curved linear array transducer, and volumetric array transducer. We will also discuss the limitations of the current PAI systems and describe latest techniques being developed to address these for further enhancing the image quality of PAI for successful clinical translation.

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Experimental evaluation of cMUT and PZT transducers in receive only mode for photoacoustic imaging

Cited by 10 publications

References 11 publications

Simultaneous transrectal ultrasound and photoacoustic human prostate imaging

Simultaneous transrectal ultrasound and photoacoustic human prostate imaging

Quantitative comparison of PZT and CMUT probes for photoacoustic imaging: Experimental validation

Clinical photoacoustic imaging platforms

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