A masonry made of hollow concrete blocks in modern constructions differs from the traditional one in that the empty space (up to 70%) makes it possible to create complex high-strength load-bearing structures by filling the voids with monolithic or reinforced concrete. The aim of this study was to examine specimens of concrete structures made of hollow blocks with voids filled with concretes with various features. The research methodology is based on the results of numerical and experimental tests. Laboratory studies were conducted to determine the influence of the concrete filling on strength, deformability and the nature of destruction of the experimental specimens. The numerical analysis was performed on the basis of FEM with the use of the ANSYS 2021 R1 software. The method for determining the load capacity of multi-component structures using strain diagrams of constituent materials has been improved. There is strong agreement between the numerical and experimental results for all masonry prisms. Additionally, a good correlation was observed between the experimental results and the analytical calculations performed using the proposed methodology.