Experimental evaluation of neural probe's insertion induced injury based on digital image correlation method

Zhang, Wenguang; Ma, Yakun

doi:10.1118/1.4938064

Cited by 11 publications

(1 citation statement)

References 19 publications

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“…Urrea et al [25] examined the implantation process of stainless-steel hollow needles with different outer diameters and speeds, predicting potential damage by evaluating the friction coefficient between the needles and hydrogel. Zhang et al [26] developed an evaluation system based on a microscopy digital image correlation method for detecting brain tissue damage caused by neural probe insertion. The system can extract tissue deformation information from the captured speckle patterns, assessing the brain tissue damage induced by the neural probe.…”

Section: Introductionmentioning

confidence: 99%

Experimental Study of the Implantation Process for Array Electrodes into Highly Transparent Agarose Gel

Wang,

Yan,

Jiao

et al. 2024

Materials

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Brain–computer interface (BCI) technology is currently a cutting-edge exploratory problem in the field of human–computer interaction. However, in experiments involving the implantation of electrodes into brain tissue, particularly high-speed or array implants, existing technologies find it challenging to observe the damage in real time. Considering the difficulties in obtaining biological brain tissue and the challenges associated with real-time observation of damage during the implantation process, we have prepared a transparent agarose gel that closely mimics the mechanical properties of biological brain tissue for use in electrode implantation experiments. Subsequently, we developed an experimental setup for synchronized observation of the electrode implantation process, utilizing the Digital Gradient Sensing (DGS) method. In the single electrode implantation experiments, with the increase in implantation speed, the implantation load increases progressively, and the tissue damage region around the electrode tip gradually diminishes. In the array electrode implantation experiments, compared to a single electrode, the degree of tissue indentation is more severe due to the coupling effect between adjacent electrodes. As the array spacing increases, the coupling effect gradually diminishes. The experimental results indicate that appropriately increasing the velocity and array spacing of the electrodes can enhance the likelihood of successful implantation. The research findings of this article provide valuable guidance for the damage assessment and selection of implantation parameters during the process of electrode implantation into real brain tissue.

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Section: Introductionmentioning

confidence: 99%

Experimental Study of the Implantation Process for Array Electrodes into Highly Transparent Agarose Gel

Wang,

Yan,

Jiao

et al. 2024

Materials

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Implanting mechanics of PEG/DEX coated flexible neural probe: impacts of fabricating methods

Zhang

Zhou

et al. 2021

Biomed Microdevices

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A novel neural electrode with micro-motion-attenuation capability based on compliant mechanisms—physical design concepts and evaluations

Zhang

Tang

2018

Med Biol Eng Comput

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In order to solve the problem of the short lifespan of the neural electrode caused by micro motion, this study designed a novel neural electrode based on lumped compliance compliant mechanism to control different modes of micro-motion in a more effective way. According to the mathematical modeling of the novel neural electrode, the equivalent bending stiffness and equivalent tensile (compression) stiffness were calculated. The results of the finite element analysis based on the mathematical modeling revealed that the novel neural electrode showed excellent micro-motion-attenuation capability. The static analysis results showed that the novel design dramatically reduced the maximum displacement of the brain in 51% and the maximum stress in 41% under longitudinal micro-motion environment. It also effectively reduced the 5.1% maximum stress while maintaining the maximum displacement under lateral micro-motion environment. The experimental results based on the tissue injury evaluation system also confirmed that the novel electrode is more effective in micro-motion attenuation than the reference one. In detail, the strain of the brain tissue caused by the implantation of the neural electrode was decreased by 1.26 to 27.84% at the insertion depth of 3 mm, and 0.522 to 17.24% at the insertion depth of 4.5 mm, which has convinced the effectiveness of the design. Graphical abstract The schematic of the novel neural electrode and evaluationsystem of tissue injury.

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Experimental evaluation of neural probe's insertion induced injury based on digital image correlation method

Cited by 11 publications

References 19 publications

Experimental Study of the Implantation Process for Array Electrodes into Highly Transparent Agarose Gel

Experimental Study of the Implantation Process for Array Electrodes into Highly Transparent Agarose Gel

Implanting mechanics of PEG/DEX coated flexible neural probe: impacts of fabricating methods

A novel neural electrode with micro-motion-attenuation capability based on compliant mechanisms—physical design concepts and evaluations

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