Experimental evaluation of portal venous pulsatile flow synchronized with heartbeat intervals

Abstract

Blood flow in the portal vein is pulsatile and influenced by both the inferior vena cava and the arterial system in a complex manner.

Experimental evaluation of portal venous pulsatile flow synchronized with heartbeat intervals: effects of vascular clamping on portal hemodynamics

“…We previously showed that blood flow in the portal vein was pulsatile, showing a pattern similar to that of the inferior vena cava, as well as a pattern similar to that of the arterial system [1]. Our results suggested that pulsatile flow in the portal vein was derived from flow in the inferior vena cava (right-heart system) and arteries (left-heart system).…”

“…6). Similar time courses of pressure and flow are characteristics of arterial flow [1]. Portal venous flow before clamping of the mesenteric artery was characteristic of arteries.…”

“…Abu-Yousef [8] reported that even healthy persons without heart disease had pulsatile flow in the portal vein and that portal venous flow waveforms resembled hepatic venous flow waveforms. We also found that flow waveforms in the intrahepatic portal vein resembled those in the hepatic vein and therefore started to study portal venous pulsatile flow [1]. These findings show that changes in hemodynamics in the right-heart system are sharply reflected in portal venous flow.…”

“…7). Prolongation of heartbeat intervals was associated with delayed onset times of inferior vena cava waves, whereas the onset times of arterial system waves generally remained stable, irrespective of the heartbeat interval [1]. PVMF was found to be derived from waves originating in the mesenteric artery, while A 0 was derived from waves originating in the inferior vena cava.…”

“…Our previous study demonstrated that pulsatile flow in the portal vein was formed by waves with characteristics of flow in the inferior vena cava (PVPP and PVPF) as well as by waves with characteristics of arterial flow (PVMP and PVMF) [1]. In the present study, we artificially produced changes in blood flow by clamping vessels to examine the effects on flow wave pulsation in the portal vein.…”