Three-dimensional (3D) spacers prove characteristics in structures and performance which can be to be the main object of a high number of research and applications in specialist markets (from small medical devices to large engineering structure) where the demands of high performance are severe. Nevertheless, much of the research has come from academia and there are few relatively small companies that, even if have expertise, lack the resources to develop R&D programmes. Among these markets, applications in acoustic performance demonstrate that 3D spacers fulfil the increasing request of acoustic performance and aesthetic for interior designs [1]. This performance is topic of several papers, but a comprehensive and updated review is missing. The paper presents a systematic review of research that explore the acoustic performance of 3D spacer fabrics. A scientific approach to develop textile based acoustic materials/structures is deeply desired. Desirable features of acoustic materials in terms of ecology and economy must be explored, such as recyclability, light weight, and cost effectiveness. Design is a challenging task because varying material types together with acoustic textiles can be used simultaneously in different shapes, thicknesses, sequences, perforation, and groove properties. It aims to understand the limitations and the potentialities respect to current market of acoustic materials. The paper underlines how the results obtained by the measurement surveys open to new opportunities for room acoustics applications.