There have been a number of studies concerning the integrity of high-strength carbon steel pipe elbows weakened by local pipe wall thinning, the latter can be typically caused by flow accelerated erosion/corrosion. In particular, the focus of several recent studies was on low cycle fatigue behavior of damaged elbows, mainly, in relation to strength and integrity of piping systems of nuclear power plants subjected to extreme loading conditions, such as earthquake or shutdown. The current paper largely adopts the existing methodology, which was previously developed, and extends it to copper-nickel elbows, which are widely utilized in civil infrastructure in seismically active regions. FE (finite element) studies along with a full-scale testing program were conducted and the outcomes are summarized in this article. The overall conclusion is that the tested elbows with various severity of local wall thinning, which were artificially introduced at different locations, demonstrate a strong resistance against low cycle fatigue loading. In addition, elbows with wall thinning defects possess a significant safety margin against seismic loading. These research outcomes will contribute to the development of strength evaluation procedures and will help to develop more effective maintenance procedures for piping equipment utilized in civil infrastructure.