2014
DOI: 10.1038/hdy.2014.49
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Experimental evolution and the dynamics of genomic mutation rate modifiers

Abstract: Because genes that affect mutation rates are themselves subject to mutation, mutation rates can be influenced by natural selection and other evolutionary forces. The population genetics of mutation rate modifier alleles has been a subject of theoretical interest for many decades. Here, we review experimental contributions to our understanding of mutation rate modifier dynamics. Numerous evolution experiments have shown that mutator alleles (modifiers that elevate the genomic mutation rate) can readily rise to … Show more

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Cited by 59 publications
(70 citation statements)
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“…For example, a high prevalence of mutator strains in pathogens has been attributed to a continued need to evade the host immune system, and pathogen genes mediating host interactions are subject to selection favoring novel variants. 46 In long-term mutualisms, the host immune system may likewise regulate endosymbionts. 47 In principle, symbiont mutations that overcome host control may be favored by symbiont-level selection.…”
Section: Shifts In Evolutionary Processes: a Priori Predictionsmentioning
confidence: 99%
“…For example, a high prevalence of mutator strains in pathogens has been attributed to a continued need to evade the host immune system, and pathogen genes mediating host interactions are subject to selection favoring novel variants. 46 In long-term mutualisms, the host immune system may likewise regulate endosymbionts. 47 In principle, symbiont mutations that overcome host control may be favored by symbiont-level selection.…”
Section: Shifts In Evolutionary Processes: a Priori Predictionsmentioning
confidence: 99%
“…In largely asexually reproducing populations, an allele that causes an increased mutation rate (a 'mutator') can remain linked to any beneficial mutations that it induces, and hence increase in frequency by 'hitchhiking' [100]. Adaptation in microbial populations indeed often leads to evolution of mutator strains whose DNA repair is defective, and which produce beneficial mutations more frequently than non-mutators, resulting (often temporarily) in an increased mutation rate [107]. In sexual populations, however, recombination quickly disassociates mutator alleles from any beneficial mutations, and their increased frequency of deleterious mutations favours alleles conferring lower mutation rates [61,108].…”
Section: Is There An Evolvability Problem? (A) Genetic Variation and mentioning
confidence: 99%
“…(b) The evolution of mutation rates, sex and genetic recombination Selection on variants that alter the mutation rate has been intensively studied, both theoretically and experimentally [61,107,108], with the aim of understanding the outcome of the conflict between the potential advantage of producing beneficial mutations, and the fact that most mutations that affect fitness are deleterious [27,61]. In largely asexually reproducing populations, an allele that causes an increased mutation rate (a 'mutator') can remain linked to any beneficial mutations that it induces, and hence increase in frequency by 'hitchhiking' [100].…”
Section: Is There An Evolvability Problem? (A) Genetic Variation and mentioning
confidence: 99%
“…Mutators are Evolutionary dynamics of integronscharacterized by an elevated mutation rate, usually caused by mutations in genes responsible for DNA mismatch correction (Denamur and Matic, 2006;Raynes and Sniegowski, 2014). In a well-adapted population, mutators are disfavored because of their increased genetic load.…”
Section: Evolutionary Dynamics Of Integronsmentioning
confidence: 99%