Acoustic Doppler Profilers (ADPs) are routinely used to measure flow velocity in the ocean, enabling multi-points measurement along a profile while Acoustic Doppler Velocimeters (ADVs) are laboratory instruments that provide very precise point velocity measurement. The experimental set-up allows laboratory comparison of measurement from these two instruments. Simultaneous multi-point measurements of velocity along the horizontal tank profile from Single-Beam Acoustic Doppler Profiler (SB-ADP) were compared against multiple co-located point measurements from an ADV. Measurements were performed in the FloWave Ocean Energy Research Facility at the University of Edinburgh at flow velocities between 0.6 ms − 1 and 1.2 ms − 1 . This paper describes the data; the analysis of the inter-instrument comparison is presented in an associated Sensors paper by the same authors. This data-set contains (a) time series of raw SB-ADP uni-directional velocity measurements along a 10 m tank profile binned into 54 measurements cells and (b) ADV point measurements of three-directional velocity time series recorded in beam coordinates at selected locations along the profile. Associated with the data are instrument generated quality data, metadata and user-derived quality flags. An analysis of the quality of SB-ADP data along the profile is presented. This data-set provides multiple contemporaneous velocity measurements along the tank profile, relevant for correlation statistics, length-scale calculations and validation of numerical models simulating flow hydrodynamics in circular test facilities.