Experimental Glioma in Primates: A Computed Tomography Model

Kg, Rieth; G, Di Chiro; Wt, London; Jl, Sever; Sa, Houff; Pl, Kornblith; Pe, McKeever; Buonomo, Carlo; Bl, Padgett; Dl, Walker

doi:10.1097/00004728-198006000-00001

Cited by 28 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A very high exogenous uptake of essential amino-acids is an original biochemical feature of anaplastic tissues and correlates to their proliferation rate as confirmed by in vivo and in vitro studies (15,16,37). Furthermore, a metabolic alteration may be evident with PET before any CT scan signs of BBB disruption which occurs rather late in tumor development (38,39).…”

Section: Resultsmentioning

confidence: 91%

Brain tumor protein synthesis and histological grades: A study by positron emission tomography (PET) with C11-L-Methionine

et al. 1986

View full text Add to dashboard Cite

Brain protein synthesis may be evaluated in vivo by a PET three compartment methionine model. 14 human brain tumor patients were studied. Protein synthesis rate (PSR) was increased in any glial tumor even in low grades, but this increase was statistically more important in anaplastic tumor. Radiotherapy action was evaluated in two patients. Local tumoral PSR was reduced to normal brain PSR after treatment. No difference was seen in normal cortex contralateral to the lesion between pre and post radiotherapy examination. 11 C-L-Methionine incorporation measured by PET looks as a very sensitive method for studying tumor metabolism and treatment effects.

show abstract

Section: Resultsmentioning

confidence: 91%

Brain tumor protein synthesis and histological grades: A study by positron emission tomography (PET) with C11-L-Methionine

et al. 1986

View full text Add to dashboard Cite

show abstract

“…The polyomavirus JC virus (JCV) readily infects its human host (30) and in immunocompromised individuals may cause the fatal demyelinating brain disease progressive multifocal leukoencephalopathy (32). JCV also induces a high incidence of tumors in hamsters (33,50) and rats (29), and it is the only human virus known to cause solid tumors in primates (19,37). Although it functions efficiently in vivo, JCV, unlike the closely related polyomaviruses simian virus 40 (SV40) and BK virus (BKV), is highly restricted in its lytic and transforming behavior in tissue culture (for a review, see reference 49).…”

mentioning

confidence: 99%

Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40: identification of sequences important for efficient transformation

Bollag

Chuke

Frisque

1989

J Virol

129

View full text Add to dashboard Cite

Hybrid viral genomes were used to investigate the influence of specific polyomavirus sequences on the transforming behavior of JC virus (JCV). One set of chimeric DNAs was made by exchanging the regulatory regions between JCV and simian virus 40 (SV40) or JCV and BK virus (BKV). A second set of constructs was produced that expressed hybrid JCV-BKV T proteins under the control of either JCV or BKV regulatory signals. Transformation of Rat 2 cells with the parental and chimeric DNAs indicated that both the JCV regulatory signals and the sequence encoding the amino terminus of T protein contributed to the restricted transforming behavior of this virus. Analysis of the viral proteins in the transformed rat cells indicated that the large T antigens of JCV and BKV were less stable than their SV40 counterpart, that small t protein was produced in JCV transformants, and that the subpopulation of T antigen that forms a stable complex with cellular p53 protein was smaller in JCV-transformed cells than in SV40or BKV-transformed cells. MATERIALS AND METHODSCells. Rat 2 cells (47) were cultured in Dulbecco modified Eagle medium (DMEM), supplemented with 10% fetal bovine serum (FBS), penicillin (99 U/ml), and streptomycin (73 U/ml), at 37°C in an atmosphere containing 10% CO2. 863 on August 5, 2020 by guest

show abstract

“…This is intriguing because human pinealoblastomas sometimes show retinoblastomatous differentiation, thus aligning neuroblastomas and retinoblastomas (166). It is noteworthy that primate models for JCVinduced gliomas are also available (95,141). BKV and SV40 did not induce intracranial tumours in primates (95,141,202).…”

Section: Neuro-oncogenic Properties Of Virusesmentioning

confidence: 99%

“…It is noteworthy that primate models for JCVinduced gliomas are also available (95,141). BKV and SV40 did not induce intracranial tumours in primates (95,141,202). Behaviour and pattern of metastasis of JCV-induced neuroblastomas are strikingly similar to the human counterparts (183), and based on morphological criteria, some JCV-induced tumours are indistinguishable from human neuroblastomas (134).…”

Section: Neuro-oncogenic Properties Of Virusesmentioning

confidence: 99%

Are human DNA tumour viruses involved in the pathogenesis of human neurogenic tumours?

Ibelgaufts¹

1982

Neurosurg. Rev.

View full text Add to dashboard Cite

Experimental Glioma in Primates: A Computed Tomography Model

Cited by 28 publications

References 0 publications

Brain tumor protein synthesis and histological grades: A study by positron emission tomography (PET) with C11-L-Methionine

Brain tumor protein synthesis and histological grades: A study by positron emission tomography (PET) with C11-L-Methionine

Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40: identification of sequences important for efficient transformation

Are human DNA tumour viruses involved in the pathogenesis of human neurogenic tumours?

Contact Info

Product

Resources

About