2017
DOI: 10.1111/avj.12552
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Experimental Hendra virus infection of dogs: virus replication, shedding and potential for transmission

Abstract: Objective Characterisation of experimental Hendra virus (HeV) infection in dogs and assessment of associated transmission risk. Methods Beagle dogs were exposed oronasally to Hendra virus/Australia/Horse/2008/Redlands or to blood collected from HeV‐infected ferrets. Ferrets were exposed to oral fluids collected from dogs after canine exposure to HeV. Observations made and samples tested post‐exposure were used to assess the clinical course and replication sites of HeV in dogs, the infectivity for ferrets of ca… Show more

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Cited by 22 publications
(19 citation statements)
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“…In particular, syncytia were observed at the epithelium of the nasal cavity and the lungs [99][100][101][102]. Syncytia were also observed, although more rarely, among epithelial cells of the tonsil [103] and the uterus [42]. More anecdotally, syncytia were reported from smooth muscle cells of blood vessels and macrophages [104].…”
Section: Syncytium Distribution Across Tissues Hosts and Virusesmentioning
confidence: 99%
“…In particular, syncytia were observed at the epithelium of the nasal cavity and the lungs [99][100][101][102]. Syncytia were also observed, although more rarely, among epithelial cells of the tonsil [103] and the uterus [42]. More anecdotally, syncytia were reported from smooth muscle cells of blood vessels and macrophages [104].…”
Section: Syncytium Distribution Across Tissues Hosts and Virusesmentioning
confidence: 99%
“…Horse vaccination by recombinant soluble Hendra glycoprotein G has been implemented in Australia to reduce the risk of Hendra virus spread to humans . However, lack of compliancy by horse owners and the potential for dog transmission argue for the need of developing a human vaccine . Effect of expression system was investigated for recombinant soluble attachment glycoprotein G of Hendra virus, revealing different N‐glycosite occupancy dependent on expression cell line.…”
Section: Glycosylation Analysis Of Viral Glycoproteinsmentioning
confidence: 99%
“…Our first paper, on experimental Hendra virus (HeV) infection of dogs, concludes that that the virus is not highly pathogenic in that species. However, the authors suggest that an infected dog's oral secretions may be a potential risk for transmission of the virus to humans during the acute stages of the disease before they have established an adaptive immune response …”
Section: Small Animalsmentioning
confidence: 99%
“…I find it interesting that we have two studies using immunohistochemistry for viral antigen identification that have come to opposite conclusions about intracytoplasmic staining of macrophages. Middelton et al make the point that identification of the antigen is not regarded as sufficient evidence that a particular tissue is the site of virus replication, as this may simply reflect sequestration of virus or fragments in phagocytes or cellular debris . However, Barigye et al are more confident that their positive staining does demonstrate virus survival and replication in macrophages …”
Section: Production Animalsmentioning
confidence: 99%