Experimental Herpes Simplex Encephalitis

Panitch, Hillel S.; Baringer, J. Richard

doi:10.1001/archneur.1973.00490240031003

Cited by 20 publications

(1 citation statement)

References 35 publications

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“…Although the asymmetric posture of HSV-infected rabbits has been observed earlier (Doerr and V6chting, 1920;Baringer and Griffith, 1970;Panitch and Baringer, 1973), no studies addressing neurochemical phenomena in relation to this type of motor behaviour have been reported. In the present study the most important statistical explanatory factor of the neurochemical parameters studied relating to the posture asymmetry was the ratio of HVA concentrations between the left and right nucleus accumbens.…”

Section: Neurochemistrymentioning

confidence: 90%

Brain monoamine metabolism and rotational behaviour induced by experimental herpes simplex virus encephalitis

Päivärinta

Marttila

Koulu

et al. 1991

J. Neural Transmission

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The motor behaviour and brain concentrations of dopamine, noradrenaline, serotonin and their metabolites have been examined in rabbits with experimental herpes simplex virus (HSV) brain infection achieved by unilateral corneal inoculation. The animals showed altered motor behaviour, consisting of a posture tilting to the side of inoculation and circling in the same direction, that began on day 4-5 post inoculation, and was most vigorous on day 7 post inoculation. Compared with controls, the concentration of 5-hydroxyindoleacetic acid was increased in the caudate nucleus on both sides and that of serotonin was decreased in the nucleus accumbens on the side of inoculation. The circling of the animals correlated positively with the ratio of homovanillic acid concentrations between the left and right caudate nucleus, although the actual concentrations did not differ from the controls. The posture asymmetry correlated with the ratio of the left and right nucleus accumbens homovanillic acid concentrations. The results demonstrate that experimental HSV infection in the brain alters motor behaviour, in association with changes in brain dopamine and serotonin metabolism in the major ascending monoamine systems.

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Section: Neurochemistrymentioning

confidence: 90%

Brain monoamine metabolism and rotational behaviour induced by experimental herpes simplex virus encephalitis

Päivärinta

Marttila

Koulu

et al. 1991

J. Neural Transmission

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Immunosuppressive and Cytotoxic Drugs in Dermatology

Dantzig¹

1974

Arch Dermatol

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Experimental Herpes Simplex Virus Encephalitis

Baringer¹,

Klassen²,

Grumm³

1976

Arch Neurol

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The effects of methylprednisolone sodium succinate and cytarabine have been examined in an experimental herpes simplex virus-induced encephalitis in rabbits. In this model herpes simplex virus (HSV) is normally cleared from the brains of untreated animals. Infected animals treated with large doses of methylprednisolone showed a slight delay in the rate of clearance of virus, and a minimal reduction in the inflammatory process, but did not otherwise differ from untreated controls. Animals treated with cytarabine displayed a notable rise in viral titers in brain at a time when virus had been cleared from untreated controls. Cytarabine-treated animals also showed persistence of intranuclear inclusions in the lesions, and moderate diminution in the extent of inflammatory response. Thus, while methylprednisolone appears to have little adverse effect on the encephalitic process, cytarabine, perhaps because of its immunosuppressive properties, results in a failure of normal clearance of virus from nervous system lesions.

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Experimental Herpes Simplex Encephalitis

Cited by 20 publications

References 35 publications

Brain monoamine metabolism and rotational behaviour induced by experimental herpes simplex virus encephalitis

Brain monoamine metabolism and rotational behaviour induced by experimental herpes simplex virus encephalitis

Immunosuppressive and Cytotoxic Drugs in Dermatology

Experimental Herpes Simplex Virus Encephalitis

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