Experimental Herpes neonatalis in SA 8-infected baboons (Papio cynocephalus)

Abstract

Summary 13 newborn baboons were experimentally infected with a baboon-derived herpesvirus SA 8-strain. Intratracheal infection produced herpetic tracheobronchopneumonia, intravenous inoculation resulted in adrenal necrosis similar to that in human neonatal herpes infection.Naturally occurring neonatal herpesvirus infections are of importance in the perinatal pathology of several mammalian species. Herpesvirus equi causes intrauterine infections and abortions in equine species, H. homim's is the causative agent of human neonatal herpes, the pathogenesis of which is still debated. Perinatal infection during delivery is considered to be responsible in many cases (White, 1963; Wheeler & Huffines, 1965;Hutfield, 1966; Nahmias, Josey & Naib, 1967; Naib, Nahmias, Josey & Wheeler, 1970; Zavoral, Ray, Kinnard & Nahmias, 1970;Amstey, 1970; Catalano, Safeley, Museles & Jarzynski, 1971;Hare, 1974); in others focal placental necrosis, porencephaly, microencephaly, intracranial calcifications, microphthalmus, retinal dysplasia and prenatal cutaneous herpetic lesions suggest a diaplacenlal route of infection

Respiratory System Diseases of Nonhuman Primates

“…Spontaneous herpesviral pneumonia was also reported in a hand-reared neonatal olive baboon (Papio anubis), which developed severe necrotizing pneumonia associated with intranuclear inclusion bodies in epithelium and endothelium (Wolf et al, 2006). Herpesviral tracheobronchopneumonia has been produced experimentally in newborn yellow baboons (Papio cynocephalus) inoculated intratracheally (Brack et al, 1985). Clinical disease was not described, but terminal illness developed within two days of inoculation.…”