Parallels between the dynamic response of flexible bridges under the action of wind and under the forces induced by crowds allow each field to inform the other. Wind-induced behaviour has been traditionally classified into categories such as flutter, galloping, vortex-induced vibration and buffeting. However, computational advances such as the vortex particle method have led to a more general picture where effects may occur simultaneously and interact, such that the simple semantic demarcations break down. Similarly, the modelling of individual pedestrians has progressed the understanding of human–structure interaction, particularly for large-amplitude lateral oscillations under crowd loading. In this paper, guided by the interaction of flutter and vortex-induced vibration in wind engineering, a framework is presented, which allows various human–structure interaction effects to coexist and interact, thereby providing a possible synthesis of previously disparate experimental and theoretical results.