Experimental immunology Differential effect of hesperidin on Th1, Th2, Th17, and proinflammatory cytokines production from splenocyte of Schistosoma mansoni -infected mice

Allam, Gamal; Abuelsaad, Abdelaziz S. A.

doi:10.5114/ceji.2013.34355

Cited by 11 publications

(5 citation statements)

References 63 publications

(75 reference statements)

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“…Mangiferin, present in C. genistoides extracts at the highest concentration, was reported to enhance Th1type responses such as IFN-γ production and to inhibit Th2-type responses such as IL-4 production [9]. Conversely, hesperidin, proportionally of greater importance in C. maculata extracts than the others, enhanced both IL-4 and IFN-γ production in a mouse splenocyte model [35]. However, the activity observed in this present study did not conform to those results.…”

Section: Discussionmentioning

confidence: 97%

Cyclopia Extracts Enhance Th1-, Th2-, and Th17-type T Cell Responses and Induce Foxp3+ Cells in Murine Cell Culture

et al. 2017

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, one of the traditional South African medicinal plants, and other species of the same genus offer noteworthy phenolic profiles, in particular high levels of the anti-allergic xanthone mangiferin. Hot water and 40% ethanol-water (v/v) extracts, prepared from , and were tested for immune-regulating activity using murine splenocytes and mesenteric lymph node cells. The 40% ethanol-water extracts of significantly enhanced production of several types of cytokines, including IL-4, IL-17, and IFN-, by antigen-stimulated splenocytes. A concentration-dependent response was observed, noticeably for IFN- production. The activity of the extracts did not correlate with the content of any of the major phenolic compounds, indicative that other extract constituents also play a role in immunomodulation. Additionally, the increased ratio of CD4CD25Foxp3 Treg cells to total CD4 cells indicated induction of Foxp3 cells when mesenteric lymph node cells were cultured in the presence of these two extracts. This study is the first reporting immunostimulatory activity for , which are widely consumed as the herbal tea known as honeybush, underpinning further investigations into the potential use of its extracts as adjuvants for mucosal immunotherapy.

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Section: Discussionmentioning

confidence: 97%

Cyclopia Extracts Enhance Th1-, Th2-, and Th17-type T Cell Responses and Induce Foxp3+ Cells in Murine Cell Culture

et al. 2017

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“…The amount of IL-1b, IL-4, IL-10, IL-12, IL-13, IL-17A, IFN-c and TNF-a were quantified in culture supernatants by sandwich enzyme linked immunosorbent assays (ELISA) 68 . Briefly, high protein binding ELISA plates (Nunc, Roskilde, Denmark) were coated with 2 lg/ml of capture at monoclonal antibody (eBioscience, Birmingham, AL, USA) against the target cytokine for at least 18 h 4 C in 0.05 M carbonate/bicarbonate buffer, pH 9.6.…”

Section: Determination Of Cytokine Levels In Cell Culture Supernatantsmentioning

confidence: 99%

“…At the end of the incubation periods, cell-free supernatants were harvested and stored at À80 C until used for cytokine determination assays 68 .…”

Section: Splenocyte Preparationmentioning

confidence: 99%

Ellagic acid reduces murine schistosomiasis mansoni immunopathology via up-regulation of IL-10 and down-modulation of pro-inflammatory cytokines production

Allam

Abuelsaad

Alblihed

et al. 2016

Immunopharmacology and Immunotoxicology

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“…In this context, it has been considered a potential protective factor in neurodegenerative diseases [ 13 ], by reducing neuro-inflammation in experimental stroke [ 14 ]. Moreover, its anti-oxidant [ 15 , 16 ], anti-depressive [ 17 ], anti-cancer [ 18 ], and immunomodulatory properties have also been described [ 19 , 20 , 21 , 22 , 23 ]. In particular, hesperidin has been shown to increase the production of anti-inflammatory cytokines in vitro [ 19 ], to exert an anti-asthmatic effect [ 20 , 21 ], to alter the CD4/CD8+ T cell ratio in the intestine wall of mice infected with Aeromonas hydrophila [ 22 ], and to influence the lymphocyte composition and functionality of the gut-associated lymphoid tissue in immunized rats [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Hesperidin Effects on Gut Microbiota and Gut-Associated Lymphoid Tissue in Healthy Rats

Estruel-Amades¹,

Massot-Cladera²,

Pérez-Cano³

et al. 2019

Nutrients

103

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Hesperidin, found in citrus fruits, has shown a wide range of biological properties. Nonetheless, a more in-depth investigation is required on the effects on the immune system, and in particular, on the gut-associated lymphoid tissue, together with its relationship with the gut microbiota. Therefore, we aimed to establish the influence of oral hesperidin administration on the intestinal lymphoid tissue and on the gut microbiota composition in healthy animals. Lewis rats were orally administrated 100 or 200 mg/kg hesperidin three times per week for four weeks. Microbiota composition and IgA-coated bacteria were determined in caecal content. Mesenteric lymph node lymphocyte (MLNL) composition and functionality were assessed. IgA, cytokines, and gene expression in the small intestine were quantified. Hesperidin administration resulted in a higher number of bacteria and IgA-coated bacteria, with changes in microbiota composition such as higher Lactobacillus proportion. Hesperidin was also able to increase the small intestine IgA content. These changes in the small intestine were accompanied by a decrease in interferon-γ and monocyte chemotactic protein-1 concentration. In addition, hesperidin increased the relative proportion of TCRαβ+ lymphocytes in MLNL. These results show the immunomodulatory actions of hesperidin on the gut-associated lymphoid tissue and reinforce its role as a prebiotic.

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Experimental immunology Differential effect of hesperidin on Th1, Th2, Th17, and proinflammatory cytokines production from splenocyte of Schistosoma mansoni -infected mice

Abstract: The present study was conducted to evaluate the potential effect of hesperidin on the regulating Th1, Th2, Th17, and

Cited by 11 publications

References 63 publications

Cyclopia Extracts Enhance Th1-, Th2-, and Th17-type T Cell Responses and Induce Foxp3+ Cells in Murine Cell Culture

Cyclopia Extracts Enhance Th1-, Th2-, and Th17-type T Cell Responses and Induce Foxp3+ Cells in Murine Cell Culture

Ellagic acid reduces murine schistosomiasis mansoni immunopathology via up-regulation of IL-10 and down-modulation of pro-inflammatory cytokines production

Hesperidin Effects on Gut Microbiota and Gut-Associated Lymphoid Tissue in Healthy Rats

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