Experimental immunology Non-invasive diagnosis of endometriosis based on a combined analysis of four plasma biomarkers

Yagmur, Erbil; Baştu, Ercan; Balcı, Burçin Karamustafaoğlu; Akhan, Süleyman Engin; Buyru, Faruk

doi:10.5114/ceji.2013.35204

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Immune system alterations are thought to be involved in the development of endometriosis, especially a dysfunction in immune-related cells and macrophages within the peritoneum secreting a number of products, mainly cytokines and growth factors [ 4 , 5 ]. At this level, there is an immune-inflammatory reaction that activates immune cells, together with endometriotic implants, producing high amounts of cytokines, growth factors, and angiogenic products [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical immunology Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Măluţan¹,

Drugan²,

Costin³

et al. 2015

cejoi

103

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The aim of the studyThe aim of the study was to investigate the serum pro-inflammatory cytokine profile in patients with diagnosed endometriosis.Material and methodsThe study included 160 women, who were divided in two study groups (Group I – endometriosis; Group 2 – healthy). We evaluated the serum levels of interleukin (IL)-1β, IL-5, IL-6, IL-7, and IL-12, and of tumour necrosis factor α (TNF-α) with the use of Human Multiplex Cytokine Panels.ResultsThe serum level of IL-1β, IL-6, and TNF-α is significantly higher in women with endometriosis compared to women free of disease, from the control group (mean 10.777, 183.027, and 131.326, respectively, compared to 3.039, 70.043, and 75.285, respectively; p = 0.002, p < 0.001, and p = 0.015, respectively). No significant differences in the serum levels of IL-5 and IL-12 were observed between the studied groups, and IL-7 had a very low detection rate.ConclusionsWomen with endometriosis have elevated levels of key pro-inflammatory cytokines, i.e. IL-1β, IL-6, and TNF-α. At the same time, IL-1β and IL-6 could be used as predictors for endometriosis.

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Section: Introductionmentioning

confidence: 99%

Clinical immunology Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Măluţan¹,

Drugan²,

Costin³

et al. 2015

cejoi

103

View full text Add to dashboard Cite

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“…Plasma levels of angiogenic/antiangiogenic substances are of prognostic value in obstetric triage: similar to a progressively worsening clinical course detected in women with early-onset PE, alterations in the angiogenic profi le linked to a more antiangiogenic state could be found [12].…”

Section: Discussionmentioning

confidence: 99%

Role of Soluble FMS-Like Tyrosine Kinase (SFLT-1) /Placental Growth Factor (Plgf) Ratio as Prognostic Marker for Cases of Preeclampsia

Elbishry¹,

Eldin²,

El-Shahawy³

et al. 2017

J Gynecol Res Obstet

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“…Key words: ovarian endometriosis cyst, pro-inflammatory cytokines, IL6, IL8, TNF-α Endometriosis is defined as the presence of endometrial tissue outside of the uterus. Unfortunately, this pathology is more common in fertile people aged 16-50 years, characterized by increasingly worsened pain and subfertility [1][2]. Women with endometriosis have symptoms that include chronic pelvic pain, dysmenorrhea and dyspareunia, that significantly reduce the quality of their life.…”

mentioning

confidence: 99%

Pro-inflammatory Cytokines (IL6, IL8 and TNF-a) in the Evaluation of Ovarian Endometriosis Cyst

Gobjila¹,

Craina²,

Toader³

et al. 2019

Rev. Chim.

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Endometriosis is the abnormal growth of cells (endometrial cells) similar to those that form the inside of the uterus, but in a location outside of the uterus. Endometriosis is most commonly found on other organs of the pelvis. These lesions are most commonly found on the ovaries, the Fallopian tubes, the surface of the uterus, the bowel, and on the membrane lining of the pelvic cavity (i.e. the peritoneum). We corroborate TNF-a, IL-6 and IL-8 markers with intraoperative laparoscopic on 39 patients diagnosed with endometriosis in January 2016 - December 2017, aged 20-45 years. There has been a preoperative evaluation in the patients from this that included the anamnesis, clinical examination and laboratory tests. Anamnesis recorded demographic details, patient�s personal, physiological and pathological medical history. Evaluation of preoperative investigations consisted of general and local systems examination, a gynecological examination in order to identify the specific signs of endometriosis. Making matters worse is that endometriosis exhibits significant immunological dysfunction, including the over-expression of pro-inflammatory cytokines like interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF), all of which contribute to a chronic up-regulation of painful, tissue-damaging inflammatory processes. Because the cause of endometriosis is poorly understood, there are no known ways to prevent its development.

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Experimental immunology Non-invasive diagnosis of endometriosis based on a combined analysis of four plasma biomarkers

Cited by 4 publications

References 24 publications

Clinical immunology Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Clinical immunology Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Role of Soluble FMS-Like Tyrosine Kinase (SFLT-1) /Placental Growth Factor (Plgf) Ratio as Prognostic Marker for Cases of Preeclampsia

Pro-inflammatory Cytokines (IL6, IL8 and TNF-a) in the Evaluation of Ovarian Endometriosis Cyst

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