Experimental implementation of automatic ‘cycle to cycle’ control of a chiral simulated moving bed separation

Amanullah, Mohammad; Grossmann, Cristian; Mazzotti, Marco; Morari, Manfred; Morbidelli, Massimo

doi:10.1016/j.chroma.2007.07.065

Cited by 36 publications

(33 citation statements)

References 19 publications

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“…The optimizing SMB controller developed at ETH Zurich is based on a very simple model of the unit and requires minimal tuning (Erdem et al 2004a, b;Grossmann et al 2008a, b). The optimizing SMB controller has been demonstrated effective through simulations using a virtual SMB unit for systems subject to linear and nonlinear isotherms Grossmann et al 2008b) from the experimental point of view, the controller has been successfully applied to a number of systems, including chiral separations (Amanullah et al 2007;Langel et al 2009).…”

Section: Control Approachmentioning

confidence: 99%

On-line optimizing control of the intermittent simulated moving bed process

et al. 2013

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The I-SMB process is one of the modifications to the standard SMB process that has been demonstrated both theoretically and experimentally to exhibit rather competitive performance (Katsuo and Mazzotti in J Chromatogr A 1217:1354, 2010a, 3067, 2010b Katsuo et al. in J Chromatogr A 1218:9345, 2011. This work aims at showing that also the I-SMB process can be controlled and optimized by using the optimizing on-line controller developed at ETH Zurich for the standard SMB process (Erdem et al. in Ind Eng Chem Res 43:405, 2004a, 3895, 2004b Grossmann et al. in Adsorption 14:423, 2008, AI-ChE J 54:1942008). This is achieved by using a virtual I-SMB unit based on a detailed model of the process; past experience with the on-line controller shows that the controller's behavior on a virtual platform is essentially the same as in laboratory experiments.

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Section: Control Approachmentioning

confidence: 99%

On-line optimizing control of the intermittent simulated moving bed process

et al. 2013

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“…Moreover, the online monitoring system should be able to withstand the variation in the process operating parameters such as pressure, concentration, etc. (12). Actually, for chiral separation, accurate online monitoring system remains to be challenge.…”

Section: Essence Of Improved Online-monitoring Systemmentioning

confidence: 99%

“…This method is widely used in the field of continuous chromatography including SMB. However, frequent necessity of polarimeter calibration and its sensitiveness to pressure fluctuations in the presence of impurities in the mixture drives the researchers to develop alternative online monitoring system for chiral separation (12,51,52…”

Section: Essence Of Improved Online-monitoring Systemmentioning

confidence: 99%

“…innovated so far. Despite boosting the productivity and reducing the operation costs, SMB is hard to design and control due to its hybrid nature (12). Also, it needs a considerable time to reach a cyclic steady state.…”

Section: Introductionmentioning

confidence: 99%

“…In previous publications, the optimizing controller was based on the combination of two online optical detectors, i.e. polarimeter and UV detector, to determine the product purity (12,32). However, the accuracy of the polarimeter is greatly sensitive to the variations in process operating conditions, e.g.…”

Section: Introductionmentioning

confidence: 99%

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Experimental study of optimizing control of continuous chromatographic separation process

Khoda.¹

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Optimizing control of simulated moving bed separations of mixtures subject to the generalized Langmuir isotherm

et al. 2007

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Simulated moving bed (SMB) is a cost-efficient separation technique that offers high productivity and low solvent consumption. SMB has gained importance in the pharmaceutical and fine chemical industry to perform complex separation tasks. However, an open and challenging problem is the optimal, robust operation of the SMB process. We have developed a control scheme that integrates the optimization and control of the SMB unit. A significant feature of the controller is that only minimal information of the system has to be provided, i.e. the linear adsorption behavior of the mixture to be separated and the average void fraction of the columns. Therefore, a full characterization of the adsorption behavior of the mixture and the columns is no longer required. In this 'cycle to cycle' control scheme, the measurements, optimization and control actions are performed once in every cycle. This paper presents simulation results of the control scheme applied to the separation of binary mixtures characterized by generalized Langmuir isotherms. The results are presented and analyzed in the frame of the triangle theory that has been recently extended to encompass these types of isotherms. Be-C. Grossmann · M. Morari ( ) sides, online optimum performance of the SMB unit is compared with off-line optimization carried out using genetic algorithm. The results show that the controller fulfills the product and process specifications while operating the SMB unit optimally, regardless of the different types of Langmuir isotherms that the systems exhibit.

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Experimental implementation of automatic ‘cycle to cycle’ control of a chiral simulated moving bed separation

Cited by 36 publications

References 19 publications

On-line optimizing control of the intermittent simulated moving bed process

On-line optimizing control of the intermittent simulated moving bed process

Experimental study of optimizing control of continuous chromatographic separation process

Optimizing control of simulated moving bed separations of mixtures subject to the generalized Langmuir isotherm

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