Experimental infection and adaptation ofRodentolepis nanato the Mongolian jirdMeriones unguiculatus

Abstract

A mouse-derived strain of Rodentolepis ( = Hymenolepis) nana was transferred to the Mongolian jird Meriones unguiculatus. It was found that M. unguiculatus has low susceptibility to R. nana mouse isolates. Likewise, adaptation of the parasite to jird hosts, in the absence of dexamethasone treatment, was not demonstrable, at least during ten-passage trials. Nevertheless, the parasite was able to establish, grow and develop to gravid adults in M. unguiculatus treated daily with dexamethasone. Prepatent periods in dexamethasone-treated jirds in ten-passage series ranged from 10 to 17 days post-infection (DPI), the average being 12 days, and the patent periods lasted from 18 to 30 DPI, with an average of 25 days. The population pattern of faecal egg output in immunosuppressed jirds suggests that under a daily dexamethasone treatment protocol, the parasite is able to maintain egg production as long as treatment is sustained.

Desenvolvimento e distribuição de Rodentolepis nana em Meriones unguiculatus

“…Nesse caso, as larvas cisticercóides irão se desenvolver no interior das vilosidades intestinais desse hospedeiro. Posteriormente, elas emergem na luz intestinal e se prendem, através de seus escólices, à mucosa, onde completarão seu desenvolvimento até adultos, em um período entre 15 a 20 dias (SILES-LUCAS;HEMPHILL, 2002;VIANNA;MELO, 2007).…”