1998
DOI: 10.2307/1592472
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Experimental Infection and Transmissibility of Mycoplasma synoviae with Delayed Serologic Response in Chickens

Abstract: Fifteen mycoplasma-free chickens were contact exposed to five chickens that had been experimentally infected with one of three different strains (two field strains and one laboratory strain) of Mycoplasma synoviae (MS). Culture and polymerase chain reaction (PCR) were positive by 3 days postinoculation (PI) in the experimentally infected birds. Lateral transmission was found by 7-14 days postexposure. Positive serum plate agglutination (SPA) results were detected 3-4 wk after positive culture and/or PCR in ind… Show more

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Cited by 30 publications
(30 citation statements)
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“…The highest level of sialidase activity observed was for strain WVU1853 T , which was associated with severe systemic disease in experimentally infected birds (13). Intermediate levels of sialidase activity were observed for F10-2AS, a strain associate with respiratory lesions (22); FMT33 and FMT126, whose parent isolate FMT induced respiratory lesions and embryo lethality in chickens (22,23); MS117 and MS178, which originated from an outbreak of severe synovitis (5,6); and for strain K3344, which was associated with respiratory lesions in experimentally infected chickens (8). Low levels of sialidase activity were observed for strains K4907A, K5016, K5113 and K5599A, which were not associated with pathologic lesions.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The highest level of sialidase activity observed was for strain WVU1853 T , which was associated with severe systemic disease in experimentally infected birds (13). Intermediate levels of sialidase activity were observed for F10-2AS, a strain associate with respiratory lesions (22); FMT33 and FMT126, whose parent isolate FMT induced respiratory lesions and embryo lethality in chickens (22,23); MS117 and MS178, which originated from an outbreak of severe synovitis (5,6); and for strain K3344, which was associated with respiratory lesions in experimentally infected chickens (8). Low levels of sialidase activity were observed for strains K4907A, K5016, K5113 and K5599A, which were not associated with pathologic lesions.…”
Section: Discussionmentioning
confidence: 99%
“…Strain WVU1853 T has been most commonly reported to cause airsacculitis and synovitis (21), however, experimental infection studies indicated that this strain is capable of systemic spread and the generation of lesions in multiple tissues (13,22). Strain K3344 was isolated during an outbreak of apparent reproductive disease in a breeder flock in 1992, but was demonstrated to produce respiratory lesions during experimental infections (8). Strains MS117, MS173, and MS178 were isolated during an outbreak of severe synovitis in Argentina (5).…”
Section: Synoviae Strainsmentioning
confidence: 99%
“…The FMT strain, originally isolated from chicken trachea, induced minor respiratory lesions following experimental infection [3]; stocks FMT33 and FMT126 were derived from serial in vitro passages of FMT. Strain K3344 was isolated during an outbreak of apparent reproductive disease in a breeder flock in 1992, but was demonstrated to produce respiratory lesions during experimental infections [48]. Strains MS173 and MS178 were isolated during an outbreak of severe synovitis in Argentina [49].…”
Section: Mycoplasma Synoviae Strains and Culture Conditionsmentioning
confidence: 99%
“…The delayed serological response detected in two flocks, which became positive by PCR only after 7 and 16 weeks, together with the low reactive number of sera, indicates that the sensitivity of SPA is below than expected and should be carefully evaluated when establishing an epidemiological surveillance program for MS. It has been suggested previously that MS surveillance should not be exclusively based in SPA, but it should be supported by PCR and attempts to isolate the agent (Ewing et al, 1998).…”
Section: Serologymentioning
confidence: 99%
“…MS-free farms may also become suddenly positive, and the source of infection may not be identified in order to guide biosecurity efforts. Another aspect of diagnosis is that serological tests do not always show the same result and SPA seems to have low sensitivity in some situations (Ewing et al, 1998).…”
Section: Introductionmentioning
confidence: 99%