Experimental Infection of Lambs with Muellerius Capillaris

Rose, J. H.

doi:10.1016/s0368-1742(59)80040-0

Cited by 25 publications

(18 citation statements)

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“…However, there was a marked discrepancy between the larval output in Cat B and in Cat A, even allowing for the difference in quantity of the initial infecting dose, since the former produced but 20% of the number excreted by Cat A. Rose (1959), with respect to Muellerius capillaris, found that only 12% of an infecting dose of larvae was eventually established in the lungs of experimental lambs, the rest having failed to overcome the difficulties of the migratory pathways and the same author also discovered that it was possible for adult females in the lungs to be isolated in inflammatory nodules and thereby be infertile. Such findings, applied to the lungworm of the cat, are sufficient to explain the variability of larval production in the two cats of the above experiment.…”

Section: Discussionmentioning

confidence: 97%

The Output of First Stage Larvae by Cats Infested with Aelurostrongylus abstrusus

Hamilton

McCaw

1968

J. Helminthol.

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Aelurostrongylus abstrusus, the lungworm of the cat, has a world wide distribution and has been reported from countries as far apart as America, Great Britain and Palestine. It has a complex life cycle insofar as a molluscan intermediate host is essential and it is possible that auxiliary hosts also play an important part. In Britain, the incidence of active infestation of cats with the parasite has been recorded as 19·4% (Lewis, 1927) and 6·6% (Hamilton, 1966) but the latter author found that, generally, the clinical disease produced by the parasite was of a mild nature. It is known that the average patent period of the infestation in the cat is 8–13 weeks and it seems likely that, in that time, a considerable number of first stage larvae would be evacuated. Information on that point is not available and the object of the following experiment was to ascertain the number of larvae produced by cats during the course of a typical infestation.

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Section: Discussionmentioning

confidence: 97%

The Output of First Stage Larvae by Cats Infested with Aelurostrongylus abstrusus

Hamilton

McCaw

1968

J. Helminthol.

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“…The distribution of cysts of U. pallikuukensis within the lung lobes contrasts with that for species in the related genera Cystocaulus and Muellerius in sheep (Gerichter 1951;Kassai 1957;Rose 1959;Boch and Nurnberg 1962;Sedlmeier et al 1969). Whereas these parasites form primarily subpleural nodules most often along the obtuse margins of the diaphragmatic lobes, the majority of the cysts of U. pallikuukensis were found deeper in the parenchyma.…”

Section: Cyst Distribution and Characteristicsmentioning

confidence: 85%

“…Among other Muelleriinae these range from 25 to 59 days for Cystocaulus ocreatus and Muellerius capillaris (Davtyan 1949, cited in Boev 1975Gerichter 1951;Rose 1959;Svarc andZmoray 1960, cited in Boev 1975;Azimov et al 1973, cited in Boev 1975. Among the distantly related Protostrongylinae of bighorn sheep (Ovis canadensis), prepatent periods of 45-54 days are typical for Protostrongylus stilesi and P. rushi (Fougere-Tower and Onderka 1988).…”

Section: Prepatent Periodmentioning

confidence: 99%

Experimental infections of muskoxen (<i>Ovibos moschatus</i>) and domestic sheep with <i>Umingmakstrongylus pallikuukensis</i> (Nematoda: Protostrongylidae): parasite development, population structure, and pathology

Kutz¹,

Hoberg²,

Polley³

1999

Can. J. Zool.

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Three captive muskoxen (Ovibos moschatus) were successfully infected with third-stage larvae of Umingmakstrongylus pallikuukensis digested or emerged from the slugs Deroceras reticulatum and D. laeve, for the first time completing the life cycle of this parasite under experimental conditions. The course of parasite development and patency was followed for 26 months post infection (p.i.) using fecal examinations and radiography. The prepatent periods in two of the muskoxen were 91 and 95 days and the patent period in one extended for 23 months. Larval production peaked 13-14 months p.i. On postmortem of two of the muskoxen at months 14 and 26 p.i., adult parasites were found only within pulmonary cysts and cysts were randomly distributed between left and right lungs. Cyst dimensions were positively correlated with the number of adult parasites they contained. On postmortem of the third muskox at day 97 p.i., not all adult parasites were within typical cysts; two were found free in interlobular septa. Firststage larvae were recovered from lung cysts of this animal but not from feces. Lung pathology in all three muskoxen appeared localized and associated with the adult nematodes. Infection of two sheep with third-stage larvae of U. pallikuukensis did not result in parasite establishment.Résumé : Nous avons réussi à infecter trois Boeufs-musqués (Ovibos moschatus) en captivité au moyen de larves de troisième stade d'Umingmakstrongylus pallikuukensis digérées ou émergées de limaces Deroceras reticulatum et D. laeve, et c'est la première fois que tout le cycle de ce parasite se déroule avec succès dans des conditions expérimentales. Le développement du parasite et l'apparition des symptômes de l'infection ont été observés pendant 26 mois après le début de l'infection par examen des fèces et par radiographie. La période précédant l'apparition des symptômes a été évaluée à 91 et 95 jours chez deux boeufs-musqués et la période symptomatique a duré 23 mois chez l'un d'eux. La production de larves a atteint son maximum 13-14 mois après l'infection. L'examen postmortem de deux des animaux aux mois 14 et 26 de l'infection a révélé la présence de parasites adultes, mais seulement dans des kystes pulmonaires répartis au hasard dans les deux poumons. La taille de ces kystes était directement reliée au nombre de parasites adultes qu'ils contenaient. L'examen postmortem du troisième animal, au jour 97 de l'infection, a révélé que les parasites adultes n'étaient pas tous dans des kystes typiquees, puisque deux d'entre eux ont été trouvés libres dans les septums interlobulaires. Des larves de premier stade ont été repérées dans des kystes pulmonaires, mais pas dans les fèces. La pathologie de ces trois boeufs-musqués semblait bien localisée et associée à la présence des nématodes adultes. Les tentatives d'infection de trois ovidés au moyen de larves de troisième stade d'U. pallikuukensis ont échoué.[Traduit par la Rédaction] 1572 Kutz et al.

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“…However, the results were variable since only three of the animals showed active parasitological infestation, and in each of these the number of first stage larvae excreted in the faeces was considerably fewer than that produced by orally infected cats which had been given a similar dose of larvae. While it is realized that the output of larvae may not always be a true indication of the number of adult females in the lungs (Rose, 1959), nevertheless, comparison of the pulmonary lesions suggested that a smaller number of adults had been present in the lungs of the cats infected by the subcutaneous route than in those infected orally. The latter aspect is not discussed by Wade and Swanson (1958) with regard to the subcutaneous infection of calves with Dictyocaulus viviparus.…”

Section: Discussionmentioning

confidence: 99%

Parenteral Infection of the Cat by Larvae of Aelurostrongylus abstrusus

Hamilton

1969

J. Helminthol.

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The lungworm, Aelurostrongylus abstrusus, is a common parasite of the domestic cat in Great Britain and produces pulmonary lesions in that species which are occasionally severe. The disease may be reproduced experimentally either by the oral administration of third stage larvae which have been extracted from infected molluscs or by feeding the latter, themselves. For experimental purposes, the former procedure is preferred but the main disadvantage is that an infecting dose must be given on several occasions and over a period of days if sickness, with consequent loss of larvae, is to be avoided. Parenteral administration would, therefore, be advantageous. It is known that pulmonary infections have been produced in calves by the subcutaneous administration of larvae of Dictyocaulus viviparus (Wade and Swanson, 1958), in pigs by the intravenous and intratracheal injection of Metastrongylus spp. larvae (Kelley & Krous, 1961) and in sheep by the intravenous inoculation of Dictyocaulus filaria larvae (Michel and Sinclair, 1963). As neither intravenous nor intratracheal administration is particularly desirable in cats, it was resolved to attempt the reproduction of lungworm disease in that species by the subcutaneous injection of third stage larvae of Aelurostrongylus abstrusus.

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Experimental Infection of Lambs with Muellerius Capillaris

Cited by 25 publications

References 0 publications

The Output of First Stage Larvae by Cats Infested with Aelurostrongylus abstrusus

The Output of First Stage Larvae by Cats Infested with Aelurostrongylus abstrusus

Experimental infections of muskoxen (<i>Ovibos moschatus</i>) and domestic sheep with <i>Umingmakstrongylus pallikuukensis</i> (Nematoda: Protostrongylidae): parasite development, population structure, and pathology

Parenteral Infection of the Cat by Larvae of Aelurostrongylus abstrusus

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