Experimental infection of spongiform encephalopathy cattle in goats

Abstract

Ðåçþìå. Íà êîçàõ áåëîé ðóññêîé ïîðîäû è äâóõ êîçëÿòàõ, ðîäèâøèõñÿ îò çàðàaeåííûõ âîçáóäèòåëåì BSE ìàòåðåé, èçó÷åíû êëèíè÷åñêèå ñèìïòîìû, ïàòîãèñòîëîãè÷åñêèå èçìåíåíèÿ è îòëîaeåíèå ïðèîííîãî áåëêà â ÖÍÑ, âûÿâëÿåìûå èììóíîãèñòîõèìè÷åñêèì ìåòîäîì. Êëèíè÷åñêèå ñèìïòîìû è õàðàêòåð ïàòîãèñòîëîãè÷åñêèõ èçìåíåíèé â ÖÍÑ ó êîç ïðè ýêñïåðèìåíòàëüíîé èíôåêöèè BSE ïðàêòè÷åñêè íå îòëè÷àþòñÿ îò òàêîâûõ ïðè ñêðåïè. Èíôèöèðîâàííûå aeèâîòíûå ìîãóò ïîãèáàòü âíåçàïíî áåç ïðîÿâëåíèÿ êëèíè÷åñêèõ ïðèçíàêîâ çàáîëåâàíèÿ. Ìîëîäíÿê, ðîäèâøèéñÿ îò êîç â èíêóáàöèîííîì ïåðèîäå èíôåêöèè BSE, íàõîäÿñü ïðè ìàòåðè â ïîäñîñíûé ïåðèîä, èíôèöèðóþòñÿ âîçáóäèòåëåì. Summary. Clinical symptoms and histopathological changes were studied in goats of the white Russian breed and in two kids from experimentally BSE infected goats. The immunohistochemical method was used to detect depositions of prion protein in CNS tissues. The clinical symptoms and the Íàäòî÷åé Ã.À., ê.á.í., âåäóùèé íàó÷íûé ñîòðóäíèê ëàáîðàòîðèè ìîëåêóëÿðíîé öèòîïàòîëîãèè è ýëåêòðîííîé ìèêðîñêîïèè,