Experimental infection with mouse adenovirus in adult mice

Veen, J. Van Der; Mes, A.

doi:10.1007/bf01265648

Cited by 37 publications

(3 citation statements)

References 13 publications

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“…Thus, the delineation of serotypes of murine adenoviruses still requires further study. A partial crossing in CF of mouse adenovirus with human groupspecific antigen (Table 2) was in a similar fashion also observed for the FL strain by others (7,16), as well as for ~he K87 strain (8). In all instances, human sera reacted more strongly with mouse adenovirus than vice versa.…”

Section: Discussionsupporting

confidence: 72%

Biological and biophysical characteristics of mouse adenovirus, strain FL

Wigand

Gelderblom

Özel

1977

Archives of Virology

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Mouse adenovirus, strain FL (MAV), is best propagated in primary rather than secondary cultures of mouse kidney cells. Virus release from the cells into the medium is fairly efficient; the average yield per cell is about 1000 TCID50. Morphological and other biophysical characteristics are those of a typical adenovirus: the icosahedral shell with a diameter of 74 nm, fiber projections of 29 nm length, its localization inside the infected kidney cells, a buoyant density in CsC1 of 1.34 g/ml, inhibition of multiplication by inhibitors of DNA synthesis. The thermostability is higher than that of human adenoviruses, whereas, in contrast to these, MAV is inactivated to a great extent by trypsin. Complete or incomplete hemagglutinin or toxin-like activity were not detected. The virus shows no cross-neutralization with human adenoviruses and a one-side cross-reaction with another murine adenovirus strain K-87. Soluble complement-fixing antigen of MAX exhibits a sedimentation rate of 12S identical to the hexon component of human adenoviruses; both antigens show a partial antigenic relationship in tests with appropriate antisera.

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Section: Discussionsupporting

confidence: 72%

Biological and biophysical characteristics of mouse adenovirus, strain FL

Wigand

Gelderblom

Özel

1977

Archives of Virology

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“…MAdV‐1‐induced humoral responses have been studied in outbred and inbred mice. Sublethal infection of outbred mice leads to high neutralizing antibody titers 2 weeks after infection that increase for a year before declining . Infection of inbred mice leads to B cell proliferation in the spleen 10 dpi, stimulating predominantly IgG2a antibody .…”

Section: Madv‐1 Pathogenesis—tropism Adaptive Immune Responsesmentioning

confidence: 99%

“…Like HAdVs, MAdV‐1 persists in the host after acute infection . MAdV‐1 is detected in brains, spleens, and kidneys of outbred mice up to 55 weeks after intraperitoneal infection , and in urine for up to 2 years . After intranasal inoculation, MAdV‐1 viral genomes can be detected in the hearts of inbred mice at 9 weeks postinfection .…”

Section: Madv‐1 Pathogenesis—persistence and Host Genetics Of Susceptmentioning

confidence: 99%

Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host

Hemmi

Spindler

2019

FEBS Letters

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Small laboratory animals are powerful models for investigating in vivo viral pathogenesis of a number of viruses. For adenoviruses (AdVs), however, species-specificity poses limitations to studying human adenoviruses (HAdVs) in mice and other small laboratory animals. Thus, this review covers work on naturally occurring mouse AdVs, primarily mouse adenovirus type 1 (MAdV-1), a member of the species Murine mastadenovirus A. Molecular genetics, virus life cycle, cell and tissue tropism, interactions with the host immune response, persistence, and host genetics of susceptibility are described. A brief discussion of MAdV-2 (member of species Murine mastadenovirus B) and MAdV-3 (member of species Murine mastadenovirus C) is included. We report the use of MAdVs in the development of vectors and vaccines.

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Adenoviruses of Animals

Ishibashi

Yasue

1984

The Adenoviruses

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Experimental infection with mouse adenovirus in adult mice

Cited by 37 publications

References 13 publications

Biological and biophysical characteristics of mouse adenovirus, strain FL

Biological and biophysical characteristics of mouse adenovirus, strain FL

Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host

Adenoviruses of Animals

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