2022
DOI: 10.3390/v14071387
|View full text |Cite
|
Sign up to set email alerts
|

Experimental Infections of Pigs with African Swine Fever Virus (Genotype II); Studies in Young Animals and Pregnant Sows

Abstract: African swine fever is an important viral disease of wild and domestic pigs. To gain further knowledge of the properties of the currently circulating African swine fever virus (ASFV), experimental infections of young pigs (approximately 8 weeks of age) and pregnant sows (infected at about 100 days of gestation) with the genotype II ASFV Georgia/2007 were performed. The inoculated young pigs developed typical clinical signs of the disease and the infection was transmitted (usually within 3–4 days) to all of the… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

4
3
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 6 publications
(7 citation statements)
references
References 38 publications
4
3
0
Order By: Relevance
“…Conversely, and in line with our results, younger wild boar at 9 weeks of age that were oronasally infected with highly virulent strains from the Caucasus region survived for 5 to 9 days [ 7 , 10 ]. For domestic pigs, experiments with weanlings (8 to 10 weeks old) infected intranasally with the highly virulent Georgia 2007 isolate [ 27 ] or oronasally with the highly virulent Belgium 2018/1 isolate [ 19 ] showed incubation periods of 4 to 5 days, and survival times (8 to 10 days post-infection) were consistent with our study. However, variations were observed when, in the same experiment [ 19 ], 50% of 18-week-old domestic pigs inoculated intranasally with Belgium 2018/1 either died between day 7 and 14 pi or recovered.…”
Section: Discussionsupporting
confidence: 89%
See 1 more Smart Citation
“…Conversely, and in line with our results, younger wild boar at 9 weeks of age that were oronasally infected with highly virulent strains from the Caucasus region survived for 5 to 9 days [ 7 , 10 ]. For domestic pigs, experiments with weanlings (8 to 10 weeks old) infected intranasally with the highly virulent Georgia 2007 isolate [ 27 ] or oronasally with the highly virulent Belgium 2018/1 isolate [ 19 ] showed incubation periods of 4 to 5 days, and survival times (8 to 10 days post-infection) were consistent with our study. However, variations were observed when, in the same experiment [ 19 ], 50% of 18-week-old domestic pigs inoculated intranasally with Belgium 2018/1 either died between day 7 and 14 pi or recovered.…”
Section: Discussionsupporting
confidence: 89%
“…For domestic pigs, experiments with intranasally infected weanlings (8 to 10 weeks old) with the highly virulent Georgia 2007 isolate [ 27 ] or oronasally infected with the highly virulent Belgium 2018/1 isolate [ 19 ] showed incubation periods of 4 to 5 days, and survival times (8 to 10 days post-infection) were consistent with our study.…”
Section: Discussionsupporting
confidence: 88%
“…At termination, tissue samples had the lowest amount of ASFV compared with the average viremia detected in the contact spreaders as well as the pigs from all the other groups ( Figures 9 , 11C ). The recurring virus shedding, low viremia in tissues, and the lesions observed were consistent with outcomes reported in pigs with chronic ASF ( 46 , 51 56 ). Although this pig had the lowest anti-pp62 antibodies, B cell responses against other antigens included in the Ad5-ASFV cocktail were not determined and in addition, T cell responses were not evaluated.…”
Section: Discussionsupporting
confidence: 87%
“…The resistance and immunity of young pigs is lower compared to that finisher pigs. ASF causes abortions in sows in late pregnancy ( Lohse et al, 2022 ). We demonstrated the virulence of five ASFV-mutants only in young pigs.…”
Section: Discussionmentioning
confidence: 99%