Experimental inhalation of fragrance allergens in predisposed subjects: effects on skin and airways

Abstract

Inhalation of high concentrations of fragrance contact allergens apparently poses a risk for some patients of developing manifest haematogenic contact dermatitis, while the changes in the respiratory tract are limited to symptoms in some subjects without objective changes.

Fragrance materials in asthma: a pilot study using a surrogate aerosol product

“…Most of the symptoms reported were related to the throat suggesting a possible irritant effect in some individuals within the upper airway (periglottic structures). The data from this study aligns with a 2010 study conducted by Schnuch et al [24]. In contrast to the current study, Schnuch et al's study [24] was conducted with subjects selected based on a positive patch test to either isoeugenol or hydroxyisohexyl-3-carboxaldehyde.…”

“…The data from this study aligns with a 2010 study conducted by Schnuch et al [24]. In contrast to the current study, Schnuch et al's study [24] was conducted with subjects selected based on a positive patch test to either isoeugenol or hydroxyisohexyl-3-carboxaldehyde. Each subject was exposed to the vapor of a single substance, at high concentration (1000 mg/m 3 for 60 min), in an environmental exposure chamber (25 m 3 ) with an air exchange rate of 30/h.…”

“…In addition, subjects in the Schnuch et al's study [24] were sensitized to the materials of interest. In contrast, in our study, the non-, mild and moderate asthmatic individuals were not sensitized.…”

Association Between IL16 Gene Polymorphism and Allergic Contact Dermatitis Among Construction Workers

“…9 Many studies asked for a replication of these studies and further investigations to solve these conflicts in results. 9,11,30 Most of the studied cases were sensitive to mercury chloride, followed by potassium dichromate (26.6%), cobalt chloride (20%), formaldehyde (16.6%), epoxy resin (16.6%), and nickel sulfate (6.6%), respectively. Most of the cases (65.2%) sensitive to mercury chloride showed extreme positive reaction (+++).…”

“…The reading at Day 4 was considered as potassium dichromate; nickel and cobalt may also present at this time. [4][5][6][7][8][9][10][11][12][13] Patients showing doubtful reactions were excluded. Patch test reactions were graded according to the guide of the manufacturer as follows:…”