Experimental insight into the evolutionary mechanism of solid-to-hollow hydrogel

Qing, Chen; Tan, Huiyan; Tu, Yaqing; Zhang, Lidong

doi:10.1039/c9cc05947d

Cited by 10 publications

(7 citation statements)

References 37 publications

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“…Another monoclonal antibody, AMG 714 is under investigation in a phase 2 clinical trial in RCD type 2/pre lymphoma and in non-responsive CD patients. Although in concomitance with adverse events such as pneumococcal infection, hypertransaminasemia, gait disorder, tuberculosis, and cerebellar syndrome, its intravenous use at 8 mg/kg dose has been shown to be effective in improving symptoms and reducing IELs progression in RCD type 2 patients ( 78 ). Similarly, another phase 2a clinical trial tested different doses of AMG 714 in 64 non-responsive CD and found a significant symptoms improvement as well as IELs reduction ( 79 ).…”

Section: Alternative/adjuvant Therapies To Gluten Free Dietmentioning

confidence: 99%

Celiac Disease and Non-celiac Wheat Sensitivity: State of Art of Non-dietary Therapies

2020

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Gluten related disorders (GRD), which include celiac disease, non-celiac wheat sensitivity and wheat allergy are heterogeneous conditions triggered by ingestion of glutencontaining grains. Together, their prevalence is estimated to be ∼5% in the general population, however, in the last years the number of diagnoses has been rapidly increasing. To this day, the gold standard treatment for these disorders is the complete removal of gluten-containing grains from the diet. Although this therapy results effective in the majority of patients, up to 30% of individuals affected by GRD continue to present persistent symptoms. In addition, gluten-free diet has been shown to have poor nutritional quality and to cause a socioeconomic burden in patients' quality of life. In order to respond to these issues, the scientific community has been focusing on finding additional and adjuvant non-dietary therapies. In this review, we focus on two main gluten related disorders, celiac disease and non-celiac wheat sensitivity. We delineate the actual knowledge about potential treatments and their relative efficacy in pre-clinical and clinical trials.

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Section: Alternative/adjuvant Therapies To Gluten Free Dietmentioning

confidence: 99%

Celiac Disease and Non-celiac Wheat Sensitivity: State of Art of Non-dietary Therapies

2020

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“…The hollow structure was contributed by the combined actions of the Cu 2+ -induced cross-linking gradient, H 2 O 2 -catalyzed oxidation degradation of the less-cross-linked inner core, and release of gas bubbles (see the mechanism in Figure S1). 23 These processes gave rise to the hollow structure and did not destroy magnetism. The SA/ Fe 3 O 4 hollow spheres still demonstrated a superparamagnetic behavior, like neat Fe 3 O 4 particles (Figure 1c).…”

Section: Introductionmentioning

confidence: 99%

Magnetic Actuation of Hollow Swarming Spheres for Dynamic Catalysis

Yan

Zhu

Jiang

et al. 2021

ACS Appl. Mater. Interfaces

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Untethered robots with smart human–machine interactions can execute complex activities such as target cargo delivery or assembly of functional scaffolds. However, it remains challenging for fabricating microscale hollow hydrogel robots that can go with autonomous transformation of their geometric formations to adapt to unstructured environments. We herein report hydrogel-based microscopic hollow swarming spheres (HSSs) with anisotropic/isotropic alignments of Fe3O4 particles in the porous wall that can navigate under complex topography conditions by altering their geometric formation, including passing around or jumping over obstacles, assembling into various formation patterns, and swimming in a high-viscosity system. We introduce HSSs into a catalytic reaction model, in which HSSs as a catalyst can shift between water and oil phases to initiate or terminate the decomposition reaction of H2O2. This dynamic catalysis is expected to construct free-radical “living” polymerization for controlling the reaction rate and polymer dispersity index in the future.

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“…The obtained cavitary structures had spatial changes in open and noncontinuous 3D shapes and were only adaptable to specific environments with the transient characteristics. Some other hydrogels with cavitary structures were fabricated using the catalyst-decomposition method, which fulfilled solid to hollow transformation. − However, these transformations need further a catalyst system and the approaches for the preparation of high-demand complicated techniques to fulfill these transformations, , which poses a great barrier for their applications.…”

Section: Introductionmentioning

confidence: 99%

Temperature-Responsive, Manipulable Cavitary Hydrogel Containers by Macroscopic Spatial Surface-Interior Separation

Wang

Yang

Huang

et al. 2020

ACS Appl. Mater. Interfaces

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Synthetic macroscopic materials transforming from bulk solid or semisolid to a closed structure with inner cavities and distinct outer and inner microstructures are rarely reported. Here, we report an in situ method for directing spatial surface-interior separation from bulk dynamic hydrogels to closed three-dimensional (3D) hydrogel containers with inner cavities via constructing a competitively cross-linking gradient within dynamic hydrogels. The initial cross-linking of phenylboronic acid/catechol complexes is disrupted by stronger ferric ions/catechol associations, generating gradually weakened cross-linking from the outside to the inside. Both stronger cross-linking in the outer shells and sequentially weaker cross-linked interior generated during swelling closed the hydrogel container with a tunable dense outer shell, fluffy inner layer, and cavities in the core. Cellulose nanocrystals could be used to significantly improve the spatial distinction of gradient cross-linking within hydrogels, leading to an even denser outer shell with tunable shell thickness. Moreover, cavitary hydrogel containers with diverse shapes can be programmed by designing the initial shapes of dynamic hydrogels and macroscopic assembly of individual dynamic hydrogels based on their self-healing capability after subsequent surface-interior separation. These cavitary hydrogel containers demonstrate thermal-responsive gate systems with unique sustained release at higher temperature and potential reaction containers for oxygen generation on demand. This facile spatial surface-interior separation strategy for fabricating closed cavity systems has great potential for various applications.

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Experimental insight into the evolutionary mechanism of solid-to-hollow hydrogel

Abstract: The evolutionary mechanism of solid-to-hollow sodium alginate hydrogel is reported, which provides a promising concept or method basis for the preparation of hollow hydrogels with sophisticated geometries.

Cited by 10 publications

References 37 publications

Celiac Disease and Non-celiac Wheat Sensitivity: State of Art of Non-dietary Therapies

Celiac Disease and Non-celiac Wheat Sensitivity: State of Art of Non-dietary Therapies

Magnetic Actuation of Hollow Swarming Spheres for Dynamic Catalysis

Temperature-Responsive, Manipulable Cavitary Hydrogel Containers by Macroscopic Spatial Surface-Interior Separation

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