Experimental Intracerebral pO2 and pCO2 Monitoring by Mass Spectrography

Owens, Guy; Belmusto, L.; S, Woldring

doi:10.3171/jns.1969.30.2.0110

Cited by 26 publications

(1 citation statement)

References 3 publications

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“…Since cerebral anoxia precedes the neurological manifestations of a stroke, it would seem that the best way to quantitate thera-peutic effects would be to monitor changes in intracerebral gas levels. Owens, et al, 12 demonstrated that intracerebral pO2 and pCO~ could be measured instantaneously, simultaneously, and continuously with a modified mass spectrometer. This permits, for the first time, the focal study of tissue gases.…”

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confidence: 99%

Induced seizures as therapy of experimental strokes in dogs

Reed

Ciesel²,

Owens³

1971

Journal of Neurosurgery

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Intracerebral pO2, as measured in normal dog brains by a modified mass spectrometer, was found to increase following seizure activity and remain elevated at least 2 hours. These results were found with both drug- and electrically-induced seizures. The pO2 increased to a greater degree in brain tissue rendered ischemic by middle cerebral artery occlusion. A transient reflex hypertension was observed with seizure activity, but hypertension alone failed to produce significant pO2 changes. Since oxidative metabolism has been shown by other investigators to proceed at an elevated rate during seizure activity, the increased pO2 must reflect improved collateral circulation following seizure activity.

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confidence: 99%

Induced seizures as therapy of experimental strokes in dogs

Reed

Ciesel²,

Owens³

1971

Journal of Neurosurgery

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Continuous, simultaneous and instantaneous tissue gas and blood flow measurements using the mass spectrometer

Owens

Roberts

1972

Journal of Surgical Oncology

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Using a membrane permeable to gases it has been demonstrated in our laboratory that partial pressures of O2, CO2 and N2 can be monitored continuously, simultaneously and instantaneously employing a mass spectrometer. Physiologic studies in experimental animals have been carried out recording tissue gases from kidney, liver, skin and brain. Responses in these organs to changes in blood flow, blood gases, surgical trauma, and isolated perfusion have been conducted. Blood flow can be calculated by adding an inert gas (Argon) to the ventilation mixture, and recording its washout time. Simultaneous pO2, pCO2 and PAr permits focal metabolic studies previously impossible to record.

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Brain tissue pO₂ and pCO₂ levels before and after cerebral revascularization

Shields

Numoto

1980

Microsurgery

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Microvascular surgical techniques have made possible the improvement of cerebral blood flow, as demonstrated by angiography and by regional cerebral blood flow research. In this study, simultaneous mass spectrometer determinations of brain tissue and blood pO2 and pCO2 levels were used to evaluate the effectiveness of common carotid-supraclinoid carotid anastomoses (CC-SCA) in dogs. With blood pCO2 maintained at a constant level, the baseline brain tissue pO2 and pCO2 levels were recorded. During the CC-SCA procedure, which involved brain retraction and temporary vascular occlusion, brain tissue pO2 levels fell to 40% of baseline and pCO2 levels rose by 35%. Following restoration of flow via the anastomosis, the brain tissue pO2 and pCO2 levels again reached baseline.

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Experimental Intracerebral pO2 and pCO2 Monitoring by Mass Spectrography

Cited by 26 publications

References 3 publications

Induced seizures as therapy of experimental strokes in dogs

Induced seizures as therapy of experimental strokes in dogs

Continuous, simultaneous and instantaneous tissue gas and blood flow measurements using the mass spectrometer

Brain tissue pO₂ and pCO₂ levels before and after cerebral revascularization

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Experimental Intracerebral pO2 and pCO2 Monitoring by Mass Spectrography

Cited by 26 publications

References 3 publications

Induced seizures as therapy of experimental strokes in dogs

Induced seizures as therapy of experimental strokes in dogs

Continuous, simultaneous and instantaneous tissue gas and blood flow measurements using the mass spectrometer

Brain tissue pO2 and pCO2 levels before and after cerebral revascularization

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Product

Resources

About

Brain tissue pO₂ and pCO₂ levels before and after cerebral revascularization