Experimental investigation and modeling of the solubility of carvedilol in supercritical carbon dioxide

Shojaee, Safar Ali; Rajaei, Hamid; Hezave, Ali Zeinolabedini; Lashkarbolooki, Mostafa; Esmaeilzadeh, Feridun

doi:10.1016/j.supflu.2013.04.013

Cited by 31 publications

(15 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 revealed that as the temperature increases, the used correlation especially KJ model are less able to predict the behavior of the measured solubility data at the elevated temperatures. This observed trend which was previously observed for other pharmaceuticals [40][41][42][43], was reported at first by Kurnik and Reid [44]. In detail, At the high pressures, the density of the of compressed carbon dioxide moves toward a value of 972.3 kg m À3 which is not so far away from water at ambient conditions can lead to a phenomenon called "squeezing out".…”

Section: Resultssupporting

confidence: 77%

Solubility of fluvoxamine maleate in supercritical carbon dioxide

Khayyat

Kashkouli

Esmaeilzadeh

2015

Fluid Phase Equilibria

Self Cite

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 77%

Solubility of fluvoxamine maleate in supercritical carbon dioxide

Khayyat

Kashkouli

Esmaeilzadeh

2015

Fluid Phase Equilibria

Self Cite

View full text Add to dashboard Cite

“…In order to determine solubility, the residue of the solute is weighed. Typically, the gravimetric method is used together with the static method to determine solubility (Sabegh et al, 2012;Rajaei et al, 2013;Shojaee et al, 2013;Khayyat et al, 2015).…”

Section: Synthetic Methodsmentioning

confidence: 99%

Study of Solubility in Supercritical Fluids: Thermodynamic Concepts and Measurement Methods - A Review

Rad

Karimi-Sabet

Varaminian

2019

Braz. J. Chem. Eng.

View full text Add to dashboard Cite

Due to the importance of supercritical fluid technology (SFT) in different industries, it has been the subject of intense research in recent decades. Solubility is a key concept in SFT. In fact, obtaining knowledge about the theoretical concepts of solubility and related experimental measurement methods can be useful in developing and improving the quality of research in this field. This study reviews the fundamental knowledge of solubility in supercritical fluids and investigates the significant topics in this field, including high-pressure phase behavior, experimental measurement methods, modeling, and molecular simulation of solubility.

show abstract

“…In how to take in the polymer, as to suppress volatilization of the low boiling points and the lower of the physical properties of the polymer by heat which is a problem of the mulling method, it decided to apply the processing method using a supercritical fluid (SCF). SCF is known as a solvent which dissolves organic compound and is well studied [8] [9]. On the other hands, in selection of a polymer, since it became important to be low load to environment and spontaneously degraded by external environment factors, such as humidity, biodegradable polymer was picked out.…”

Section: Introductionmentioning

confidence: 99%

Supercritical Fluid Impregnation of Essential Bark Oil in Copolymers of L-Lactide with 7-Membered Cyclic Compounds

Tsutsumi

Hara²,

Ueno³

et al. 2014

JBNB

View full text Add to dashboard Cite

In order to develop a novel controlled-release material, we previously attempted to impregnate poly(L-lactide) (poly(L-LA)), poly(L-LA-ran-CL) (CL: ε-caprolactone) or poly(L-LA-ran-TEMC) (TEMC: tetramethylene carbonate) with low boiling point, organic useful compounds using supercritical carbon dioxide (scCO2) as the solvent. In this work, the factors influencing impregnation of poly (L-LA) random copolymers with useful compounds were investigated under scCO2 using the copolymers previously used. The influence of temperature, pressure, and time on the impregnation contents of the useful compounds on the copolymers was evaluated. The polymer used, which is a base of this material, was poly(L-LA-ran-CL), poly(L-LA-ran-TEMC), or poly(L-LA-ran-DXO) (DXO: 1,5-dioxepan-2-one). Statistical random copolymers of L-LA with CL, TEMC, or DXO were synthesized using Sn(oct)2 as a catalyst at 150˚C for 24 h without solvent. Preparation of the controlled-release materials was carried out using essential bark oil from Thujopsis dolabrata var. hondae and synthetic L-LA random copolymers as a base material under scCO2. The impregnation experiment, which investigated the influence of pressure, was conducted in the range of 10 to 20 MPa. The influence of temperature on impregnation was carried out at 40˚C to 100˚C. Impregnation time was varied from 1 to 5 h.

show abstract

Experimental investigation and modeling of the solubility of carvedilol in supercritical carbon dioxide

Cited by 31 publications

References 34 publications

Solubility of fluvoxamine maleate in supercritical carbon dioxide

Solubility of fluvoxamine maleate in supercritical carbon dioxide

Study of Solubility in Supercritical Fluids: Thermodynamic Concepts and Measurement Methods - A Review

Supercritical Fluid Impregnation of Essential Bark Oil in Copolymers of L-Lactide with 7-Membered Cyclic Compounds

Contact Info

Product

Resources

About