Experimental investigation into reparative osteogenesis with fibrin adhesive

Greco, Fabio; Palma, Luigi de; Specchia, Nicola; Lisai, P.

doi:10.1007/bf00454495

Cited by 19 publications

(10 citation statements)

References 6 publications

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“…For example, animal studies have produced positive results in rabbits, e.g. fibrin sealant produced enhanced bone healing when it was associated with heterologous bone grafts [113] or homologous cortical bone grafts [114]. As established in adult mongrel dogs with standardized osteochondral fractures in the left femoral condyle, the physical properties of the bony callus seemed to be enhanced by fibrin sealants [115], suggesting that sealants could potentially be used for healing periodontal bone defects.…”

Section: Applications Of Fibrin Sealantsmentioning

confidence: 96%

A review on endogenous regenerative technology in periodontal regenerative medicine

et al. 2010

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Section: Applications Of Fibrin Sealantsmentioning

confidence: 96%

A review on endogenous regenerative technology in periodontal regenerative medicine

et al. 2010

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“…18,19 Variations in experimental design, implantation site, and animal models as well as fibrinogen and thrombin concentrations are other parameters that make direct comparison of the research findings difficult. Moreover, to achieve the desired biological and/or physical properties for bone tissue engineering applications, fibrin must be reinforced, and there is a board range of nano-and other materials such as autogenous bone grafts, 20,21 allogenic bone grafts, 22,23 xenogeneic bone grafts, 24 metals, [25][26][27] ceramics, [28][29][30] …”

Section: Difficulties Involved In Assessing the Literaturementioning

confidence: 99%

A review of fibrin and fibrin composites for bone tissue engineering

Noori

Ashrafi

Vaez-Ghaemi

et al. 2017

IJN

377

256

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Tissue engineering has emerged as a new treatment approach for bone repair and regeneration seeking to address limitations associated with current therapies, such as autologous bone grafting. While many bone tissue engineering approaches have traditionally focused on synthetic materials (such as polymers or hydrogels), there has been a lot of excitement surrounding the use of natural materials due to their biologically inspired properties. Fibrin is a natural scaffold formed following tissue injury that initiates hemostasis and provides the initial matrix useful for cell adhesion, migration, proliferation, and differentiation. Fibrin has captured the interest of bone tissue engineers due to its excellent biocompatibility, controllable biodegradability, and ability to deliver cells and biomolecules. Fibrin is particularly appealing because its precursors, fibrinogen, and thrombin, which can be derived from the patient’s own blood, enable the fabrication of completely autologous scaffolds. In this article, we highlight the unique properties of fibrin as a scaffolding material to treat bone defects. Moreover, we emphasize its role in bone tissue engineering nanocomposites where approaches further emulate the natural nanostructured features of bone when using fibrin and other nanomaterials. We also review the preparation methods of fibrin glue and then discuss a wide range of fibrin applications in bone tissue engineering. These include the delivery of cells and/or biomolecules to a defect site, distributing cells, and/or growth factors throughout other pre-formed scaffolds and enhancing the physical as well as biological properties of other biomaterials. Thoughts on the future direction of fibrin research for bone tissue engineering are also presented. In the future, the development of fibrin precursors as recombinant proteins will solve problems associated with using multiple or single-donor fibrin glue, and the combination of nanomaterials that allow for the incorporation of biomolecules with fibrin will significantly improve the efficacy of fibrin for numerous bone tissue engineering applications.

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“…Some additional studies supported the standpoint that the FG stimulates bone formation. 14,15 Different sizes and different ratios of composites always have different properties; 16 it is unclear whether a different ratio of CPC and FG has different properties for bone reconstruction.…”

Section: Introductionmentioning

confidence: 99%

The mechanical and biological studies of calcium phosphate cement-fibrin glue for bone reconstruction of rabbit femoral defects

Dong¹,

Geng²,

Bi³

et al. 2013

IJN

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Abstract:In order to improve the mechanical and biological properties of calcium phosphate cement (CPC, nanometer-biomaterial) for bone reconstruction in the rabbit femoral defect model, fibrin glue (FG, the natural product, purified from the blood) was introduced at three different ratios. The CPC powder and the FG solution were mixed, respectively, at the powder/liquid (P/L) ratios (g/mL) of 1:1, 3:1, and 5:1 (g/mL), and pure CPC was used as a control. After being implanted into the femoral defect in rabbit, the healing process was evaluated by micro-computed tomography scan, biomechanical testing, and histological examination. By micro-computed tomography analysis, the P/L ratio of 1:1 (g/mL) group indicated the largest quantity of new bone formation at 4 weeks, 8 weeks, and 12 weeks after implantation, respectively. Bone volume per trabecular volume of the 1:1 group was highest in the four groups, which was 1.45% ± 0.42%, 7.35% ± 1.45%, and 29.10% ± 1.67% at 4 weeks, 8 weeks, and 12 weeks after the operation, respectively. In the biomechanical tests, the compressive strength and the elastic modulus of the three CPC-FG groups were much higher than those of the pure CPC group at the determined time point (P , 0.05). The histological evaluation also showed the best osseointegration in the 1:1 group at 4 weeks, 8 weeks, and 12 weeks after the operation, respectively. In the 1:1 group, the bone grew into the pore of the cement in the laminar arrangement and connected with the cement tightly at the 12th week after the operation. This present study indicated that the CPC-FG composite at the P/L ratio of 1:1 (g/mL) stimulated bone regeneration better than any other designed group, which suggested that CPC-FG at the P/L ratio of 1:1 has significant potential as the bioactive material for the treatment of bone defects.

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Experimental investigation into reparative osteogenesis with fibrin adhesive

Cited by 19 publications

References 6 publications

A review on endogenous regenerative technology in periodontal regenerative medicine

A review on endogenous regenerative technology in periodontal regenerative medicine

A review of fibrin and fibrin composites for bone tissue engineering

The mechanical and biological studies of calcium phosphate cement-fibrin glue for bone reconstruction of rabbit femoral defects

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