In the current study, a newly developed low photovoltaic concentrator (LCPV) equipped with nanofluid-based cooling channels, directly contacting the rare LCPV, was examined in detail. Nanofluid acts as a coolant that flowing over the back of LCPV to maintain its optimal operating temperature with the best overall performance. The coolants used are water and aluminum oxide (Al 2 O 3)/water nanofluids 1%, 2%, and 3% by volume concentration. When circulating a 3%-Al 2 O 3 /water nanofluid, the temperature of the LCPV module is dropped by 16.47 C compared to the uncooled module and keeps its operating temperature under 45 C during the experimental tests. This reduction in the LCPV module temperature with V-trough reflector mirrors in turn increased its performance. The results revealed that the daily electrical output power of the uncooled LCPV module was 1646.85 W, whereas, was 1870.55 W with (13.58%) improvement with the case of water cooling. However, cooling with 3%-Al 2 O 3 /water nanofluid, the power output of the LPVC was 2319.88 W with (24.02%) and (40.86%) enhancement compared to pure water cooling and without cooling respectively. The rise in the volume fraction ratio of Al 2 O 3 nanoparticles remarkably decreases the operating temperature of the LCPV module and improves both electrical and thermal efficiency.