Experimental investigation of aerosol deposition through a realistic respiratory airway replica: An evaluation for MDI and DPI performance

Ahookhosh, Kaveh; Yaqoubi, Shadi; Mohammadpourfard, Mousa; Hamishehkar, Hamed; Aminfar, Habib

doi:10.1016/j.ijpharm.2019.05.058

Cited by 40 publications

(9 citation statements)

References 58 publications

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“…To this end, 1% (w/v) Tween 80® in ethanol was applied on the PS and the impaction cups of each stage and allowed to dry for 30 min prior to use, ensuring optimal performance in terms of reproducibility and safety characteristics. 39,40 Three capsules (size 3) were manually filled (10 ± 0.1 mg) for each sample and then discharged for 2.7 s into the NGI operating at a flow rate of 90 l min −1 (DFM3 flow meter, Copley Scientific), to achieve an air passing volume of 4 l. 37,41 A 50 : 50 (v/v) water : ethanol mixture was used to collect the deposited powder and the quantification was carried out by determining RhB content at λ = 562 nm, using a synergy 4 multiplate UV-vis reader (BioTek, Winooski, USA). The nebulization test was repeated at least three times (3 capsules for each actuation) for each sample.…”

Section: Methodsmentioning

confidence: 99%

Rapamycin-based inhaled therapy for potential treatment of COPD-related inflammation: production and characterization of aerosolizable nano into micro (NiM) particles

Craparo,

Cabibbo,

Scialabba

et al. 2024

Biomater. Sci.

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Section: Methodsmentioning

confidence: 99%

Rapamycin-based inhaled therapy for potential treatment of COPD-related inflammation: production and characterization of aerosolizable nano into micro (NiM) particles

Craparo,

Cabibbo,

Scialabba

et al. 2024

Biomater. Sci.

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“…They noticed that the CFD prediction is very close to the best device experiment study that has been published. Furthermore, Ahookhosh et al (Ahookhosh et al, 2019) experimented with DPI and Metered-Dose Inhaler (MDI) performance. They set out to examine how they perform with the deposition parameters in a realistic human airway.…”

Section: Longest Et Al (W Longest Et Al 2019mentioning

confidence: 99%

Swirling Flow and Capillary Diameter Effect on the Performance of an Active Dry Powder Inhalers (DPI)

Taheri

Askari

Feng

et al. 2022

Preprint

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For patients with lung disease, dry powder inhalers (DPI) are profoundly beneficial. The current study introduces and develops a series of dry powder inhalers (DPIs). A capsule-based (size 0) active DPI was considered. The study aims to investigate whether swirling flow and outlet capillary diameter (dc_out) affect the percentage of emitted doses (ED) released from the capsule. Spiral vanes were added to the capillary inlet to produce a swirling flow. Computational fluid dynamics (CFD) was applied to simulate the problem. The results were compared with previous in vitro and numerical studies to validate the results. Based on the derived results, the small swirl parameter (SP) enhances the secondary flow and recirculation zone. It increases the central jet flow, which increases the ED value by about 5-20% compared to no-swirl flow. However, as the airflow rate increases, the recirculation zone enlarges, vorticities become dominant, and asymmetrical flow patterns emerge. Consequently, ED % drops significantly (more than 50%). As dc_out decreases, the vorticities around the outlet capillary become more potent, which is undesirable. Indeed, the emptying of the capsule does not happen ideally. The research provides a perspective on the device's design and DPI performance.

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“…These techniques enable a more scientific understanding of operational processes, thereby mitigating bottlenecks and building stronger confidence in QbD. Moreover, the simulation and modeling technique can be a powerful tool to study the in vitro performance of DPI formulations characterized by next-generation impactor (NGI) and human conducting , and respiratory airway models. , …”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the simulation and modeling technique can be a powerful tool to study the in vitro performance of DPI formulations characterized by next-generation impactor (NGI) 16 and human conducting 17,18 and respiratory airway models. 19,20 In addition to empirical models, three mechanistic methods are most commonly used for modeling critical inhalable dry powder manufacturing processes: the discrete element method (DEM), the population balance model (PBM), and computational fluid dynamics (CFD). The selection of different modeling methods can result in significantly different modeling outcomes due to their fundamental theory differences, which will be discussed in detail below.…”

Section: Introductionmentioning

confidence: 99%

Emerging Process Modeling Capabilities for Dry Powder Operations for Inhaled Formulations

Lou,

Ding,

et al. 2023

Mol. Pharmaceutics

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Dry powder inhaler (DPI) products are commonly formulated as a mixture of micronized drug particles and large carrier particles, with or without additional fine particle excipients, followed by final powder filling into dose containment systems such as capsules, blisters, or reservoirs. DPI product manufacturing consists of a series of unit operations, including particle size reduction, blending, and filling. This review provides an overview of the relevant critical process parameters used for jet milling, highshear blending, and dosator/drum capsule filling operations across commonly utilized instruments. Further, this review describes the recent achievements regarding the application of empirical and mechanistic models, especially discrete element method (DEM) simulation, in DPI process development. Although to date only limited modeling/simulation work has been accomplished, in the authors' perspective, process design and development are destined to be more modeling/simulation driven with the emphasis on evaluating the impact of material attributes/process parameters on process performance. The advancement of computational power is expected to enable modeling/simulation approaches to tackle more complex problems with better accuracy when dealing with real-world DPI process operations.

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Experimental investigation of aerosol deposition through a realistic respiratory airway replica: An evaluation for MDI and DPI performance

Cited by 40 publications

References 58 publications

Rapamycin-based inhaled therapy for potential treatment of COPD-related inflammation: production and characterization of aerosolizable nano into micro (NiM) particles

Rapamycin-based inhaled therapy for potential treatment of COPD-related inflammation: production and characterization of aerosolizable nano into micro (NiM) particles

Swirling Flow and Capillary Diameter Effect on the Performance of an Active Dry Powder Inhalers (DPI)

Emerging Process Modeling Capabilities for Dry Powder Operations for Inhaled Formulations

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