Experimental investigation of biostimulatory effects after polydioxanone thread insertion in a pig model

Abstract

BackgroundPolydioxanone (PDO) threads have been widely used to tighten and lift the facial soft tissue.ObjectiveThis research aims to determine the collagenation and inflammation changes that occur in the adipose tissue over time when different types of threads are implanted.Methods & MaterialsThree threads types, PDO, poly glycolic‐co‐lactic acid (PGLA), and nylon, were inserted in the subcutaneous fat of 12‐month‐old Bama miniature pigs. Collagen production and inflammatory response were evaluated by hematoxylin and eosin and Masson trichrome staining at 1, 4, 12, 24, and 48 weeks.ResultsThe integrity of the PDO thread lasted up to 24 weeks with mild inflammation and collagen production. The PGLA thread integrity lasted until 12 weeks and had a strong inflammatory response. The nylon thread's integrity was maintained for 48 weeks and showed minor inflammation and collagen production.ConclusionOur data suggest that PDO thread is the best choice for clinicians, as it has a mild action process with minimal irritation, moderate collagen production, a reasonable explanation time, with obvious bridging fibrous tissue, and thickening action for the superficial fascia.

Volumizing thread lift for subzygomatic arch (lateral cheek) depression

“…The literature extensively explores the role of PDO threads in stimulating collagen formation, with numerous studies supporting this effect. [14][15][16] For instance, Kim et al 17 In conclusion, our case presents the effectiveness of addressing subzygomatic arch depression through the application of volumizing PDO threads, showcasing it as an effective and safe technique in facial rejuvenation. The patient's satisfaction with the outcomes highlights the efficacy of this approach in achieving the desired aesthetic improvements.…”

“…The literature extensively explores the role of PDO threads in stimulating collagen formation, with numerous studies supporting this effect. 14 , 15 , 16 For instance, Kim et al. 17 compared the collagen‐producing effects of powdered PDO with poly‐L‐lactic acid, finding that powdered PDO injections induce collagen formation more effectively in a murine model.…”

Volumizing Threads (Jamber) in the Midface and Managing Side Effects: Clinical Cases

“…In a study by Su et al 10 conducted on pigs, PDO threads were found to induce mild inflammation and stimulate collagen production, peaking at 12 weeks and persisting until 48 weeks before complete degradation. Additionally, PDO threads exhibited a fibrous bridging effect, enhancing tissue connectivity and thickness without causing severe side effects such as foreign body granuloma.…”