Heat exchangers are the most significant equipment used in the industrial sites for exchanging the useful energy for many applications. It may be used either for cooling or heating but in the industrial scenario, it mostly used for cooling. In the current research development, the nanoparticles of different high thermal conductivity metals have been prepared and introduced in the low thermal performance base fluids like water, oil, ethylene glycol to enhance its quality of heat absorption in the heat exchangers. In that alumina nanoparticle played a significant role in many research applications and it has good thermal conductivity as a pure fluid. So, in this review work, the recent study of Al2O3 nanofluid with its preparation method, thermo-physical properties and its performance in varied heat exchangers have been discussed. This would enrich the knowledge and help the researchers who are interested in alumina nanofluid for their experimental works.