Experimental Investigation of Electric Signal Transmission Through Vestibular Organ Tissues

Fundamental studies to assess and restore vestibular function in patients with severe bilateral vestibular loss

“…Firstly, it means that the electrode contact tip should not exceed 0.6 mm in diameter for the rat and 0.7 mm for guinea pig to fit in the ampulla. Secondly, different surgical approaches to reach the ampulla in human (van de and in laboratory animals (Demkin et al, , 2020bDemkin, Melnichuk, Svetlik, et al, 2019) might lead to the different electroconductivity outcomes due to: 1) (partial) ampulla destruction in the case of animal models; and 2) the presence of the electrode in the canal space blocking one path of current spread in human.…”

“…This circumstance should be taken into account when designing prosthetics of the vestibular apparatus and placing electrodes in ampullae, because the transfer function of the vestibular implant depends on the configuration of the vestibular organ and location of the stimulating electrodes (Demkin, Melnichuk, Svetlik, et al, 2019).…”